| Novel HLA B*2714 and B*2708 allele associations in seronegative spondarthritis patients and haemophilia patients with chronic synovitis in India. | |
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MedLine Citation:
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PMID: 12889998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HLA B27 association with seronegative spondarthritis (SSA) has been recognized for over a decade and its association with chronic synovitis in Haemophilia patients has been recently reported. We characterized the HLA B27 subtypes in a cohort of 98 B27 positive individuals with SSA (n = 45), haemophilia with chronic synovitis (n = 21) and normal controls (n = 32), using polymerase chain reaction-based sequence specific primers (PCR-SSP) and reverse line strip (RLS) techniques. The results revealed a significant association for a novel allele B*2714 in SSA along with the previously reported B*2705 allele. We also found a significant association between haemophilia patients with chronic synovitis from India and a hitherto unidentified allele, B*2708. |
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Authors:
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U Shankarkumar; K Ghosh; D Mohanty |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Tissue antigens Volume: 62 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-31 Completed Date: 2004-04-16 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
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Languages: eng Pagination: 175-8 Citation Subset: IM |
Affiliation:
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HLA department, Institute of Immunohaematology, K.E.M. Hospital, Mumbai, India. Shankarkumar16@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis
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genetics* Female Genetic Predisposition to Disease* HLA-B Antigens / genetics* HLA-B27 Antigen / genetics* Hemophilia A / genetics* Humans India Male Synovitis / genetics* |
| Chemical | |
Reg. No./Substance:
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0/HLA-B Antigens; 0/HLA-B protein, human; 0/HLA-B27 Antigen |
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