| Novel genetic mechanisms for aortic aneurysms. | |
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MedLine Citation:
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PMID: 20446064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aortic aneurysms occur in the thoracic and abdominal sections of the aorta and are a deadly late-age-at-onset disease with complex pathobiology. Currently, the number of published genome-wide analyses including microarray-based expression profiling, DNA linkage studies, and genetic association studies is still limited and it is difficult to make generalizations about the disease pathogenesis or genetic risk factors contributing to aortic aneurysms, but it appears that thoracic aortic aneurysms differ in many ways from abdominal aortic aneurysms. Characterization of diseases at the molecular level is likely to lead to more accurate diagnoses and the use of "genomic nosology" of disease. The biggest future challenge will be to translate the genomic information to the clinic and improve our understanding of the disease processes, help us to develop better diagnostic tools, and lead to the design of new ways to manage aortic aneurysms in the era of personalized medicine. |
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Authors:
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Gerard Tromp; Helena Kuivaniemi; Irene Hinterseher; David J Carey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current atherosclerosis reports Volume: 12 ISSN: 1534-6242 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
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Languages: eng Pagination: 259-66 Citation Subset: IM |
Affiliation:
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Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, PA 17822-2611, USA. gctromp@geisinger.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aortic Aneurysm / drug therapy, etiology, genetics* Female Genetic Association Studies Humans Male Middle Aged Mutation Sex Factors Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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