Document Detail


Novel Cytotoxic Polyoxygenated Steroids from an Okinawan Sponge <i>Dysidea</i> sp.
MedLine Citation:
PMID:  22738973     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A library of extracts established from hundreds of marine organisms was screened by a cytotoxicity test. The active organic extract of an Okinawan marine sponge of the genus Dysidea was subjected to bioassay-guided fractionation to give three new polyoxygenated steroids dysideasterols F-H (1-3), together with two known related compounds (4 and 5). Their structures were confirmed by NMR and mass spectroscopic analyses. A characteristic structural feature of 2, 4 and 5 is an allylic epoxide, whereas this epoxide undergoes ring-opening by a neighbouring hydroxyl group to give a tetrahydrofuran ring in 1 and 3. All compounds 1-5 exhibited a similar cytotoxic effect with IC<inf>50</inf> values of 0.15-0.3 µM against human epidermoid carcinoma A431 cells, demonstrating that the allylic epoxide moiety was not responsible for this cytotoxic effect.
Authors:
Sudhakar V S Govindam; Bong-Keun Choi; Yukio Yoshioka; Akihiko Kanamoto; Takeshi Fujiwara; Tetsuji Okamoto; Makoto Ojika
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Publication Detail:
Type:  Journal Article     Date:  2012-05-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  76     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  999-1002     Citation Subset:  IM    
Affiliation:
Graduate School of Bioagricultural Sciences, Nagoya University.
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