| Novel Cytotoxic Isolated from Jamaican Hyptis verticillata jacq Induces Apoptosis and Overcomes Multidrug Resistance. | |
| | |
MedLine Citation:
|
PMID: 22199288 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Adult T-cell leukemia is an aggressive hematological malignancy with a poor clinical prognosis, and a rapid resistance to chemotherapy is rapid. MATERIALS AND METHODS: Cytotoxicity assay-directed fractionation identified a novel lignan-related agent, 4-methoxy-9-(3,4,5-trimethoxyphenyl)-8, 9 - dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5H)-one (4-MTDND) from the Jamaican plant Hyptis verticillata jacq, and its effects on apoptosis, cell cycle and drug resistance were elucidated. RESULTS: The novel agent, 4-MTDND, exhibited cytotoxicity against myriad cancer types, with a wide therapeutic index of 30- to 40-fold, promoted G(2)/M arrest and up-regulated expression of pro-apoptotic proteins p53 and BAX, as well as enhanced activation of caspase-3, caspase-9 and poly (ADP ribose) polymerase, consistent with apoptosis induction. Multidrug-resistant cancer cells were as susceptible to 4-MTDND as their non-resistant control counterparts, with 4-MTDND having greater efficacy compared to standard chemotherapy agents etoposide and mitoxantrone. CONCLUSION: The novel cytotoxic agent 4-MTDND induces G(2)/M arrest and apoptosis in cancer cells possibly due to direct DNA damage or interference with topoisomerase II. |
| | |
Authors:
|
Yohann White; Toshiyuki Hamada; Makoto Yoshimitsu; Mitsuyoshi Nakashima; Miho Hachiman; Tomohiro Kozako; Kakushi Matsushita; Kimiharu Uozumi; Shinsuke Suzuki; Hiroki Kofune; Tatsuhiko Furukawa; Naomichi Arima |
Related Documents
:
|
15809208 - Effect of growth hormone therapy on the proinflammatory cytokine profile in growth horm... 22253478 - 5-lipoxygenase-dependent apoptosis of human lymphocytes in the international space stat... 19265458 - The effect of 17 estradiol on the immunocompetence of japanese sea bass lateolabrax jap... 12213578 - Cell-specific regulation of apoptosis by glucocorticoids: implication to their anti-inf... 16787288 - Bacterial translocation, microcirculation injury and sepsis. 21408618 - Human macrophage responses to clinical isolates from the mycobacterium tuberculosis com... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Anticancer research Volume: 31 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
|
Languages: eng Pagination: 4251-7 Citation Subset: IM |
Affiliation:
|
Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8544, Japan. nao@m2.kufm.kagoshima-u.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytoskeleton Network and Cellular Migration Modulated by Nuclear-localized Receptor Tyrosine Kinase ...
Next Document: IGF1Ec Expression in MG-63 Human Osteoblast-like Osteosarcoma Cells.