Document Detail

Novel Copper-Based Therapeutic Agent for Anti-Inflammatory: Synthesis, Characterization, and Biochemical Activities of Copper(II) Complexes of Hydroxyflavone Schiff Bases.
MedLine Citation:
PMID:  22238015     Owner:  NLM     Status:  Publisher    
Four hydroxyflavone derivatives have been synthesized with the aim of obtaining a good model of superoxide dismutase. Better to mimic the natural metalloenzyme, copper complexes have been designed. The Cu(II) complexes of general formulae, [CuL] where L = 5-hydroxyflavone-o-phenylenediamine (L(1)H(2))/m-phenylenediamine (L(2)H(2)) and 3-hydroxyflavone-o-phenylenediamine (L(3)H(2))/m-phenylenediamine (L(4)H(2)) have been synthesized. The structural features have been determined from their analytical and spectral data. All the Cu(II) complexes exhibit square planar geometry. Redox behavior of copper complexes was studied and the present ligand systems stabilize the unusual oxidation state of the copper ion during electrolysis. The in vitro antimicrobial activities of the investigated compounds were tested against the bacterial species Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, and Pseudomonas aeruginosa and fungal species Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola, and Candida albicans. Superoxide dismutase and anti-inflammatory activities of the copper complexes have also been measured and discussed.
J Joseph; K Nagashri
Related Documents :
21582085 - Poly[[tris-[μ-2,2'-(butane-1,4-diyl-dithio)bis-(1,3,4-thia-diazole)-κn:n]copper(ii)] ...
20428585 - Stereochemistry of 4-hydroxyproline affects the conformation of conopeptides.
6618765 - Ring conformation of cyclic octapeptide cyclo (l-pro-sar)4 in the crystalline state.
22178665 - Nitrite reduction by co(ii) and mn(ii) substituted myoglobins towards understanding nec...
17489585 - Encapsulation of halides within the cavity of a pentafluorophenyl-substituted tripodal ...
21218235 - Photo-hydrogen-evolving molecular devices driving visible-light-induced water reduction...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  Applied biochemistry and biotechnology     Volume:  -     ISSN:  1559-0291     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8208561     Medline TA:  Appl Biochem Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil, 629 180, Tamil Nadu, India,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Kinetic Study of Empty Fruit Bunch Using Hot Liquid Water and Dilute Acid.
Next Document:  Enhanced Ammonia Content in Compost Leachate Processed by Black Soldier Fly Larvae.