Document Detail

Novel Compliance Index derived from digital volume pulse associated with risk factors and exercise capacity in patients undergoing treadmill exercise tests.
MedLine Citation:
PMID:  17762654     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Although large-artery stiffness is a well-known independent factor for cardiovascular risk, the importance of small-artery stiffness is not well elucidated. We have developed a novel Compliance Index as a marker of small-artery stiffness. This study aimed to determine the clinical significance of this index by evaluating 140 patients without left ventricular dysfunction referred for treadmill exercise tests. METHODS: Immediately after a 10-min rest period before the test, the pulse wave velocity and Compliance Index were measured. The patients were then given a symptom-limited treadmill test using Bruce's protocol. Our dual-channel photoplethysmography system automatically measured the area under the curve of each digital volume pulse, which represented the volume change in the finger with each heart beat. The Compliance Index was calculated by dividing the area under the curve of finger digital volume pulse by pulse pressure. RESULTS: The Compliance Index was significantly correlated with pulse wave velocity (r=-0.254, P=0.002), systolic blood pressure (r=-0.606, P<0.001), and diastolic blood pressure (r=-0.323, P<0.001). It was lower in males (3.3+/-1.4 versus 4.8+/-2.4 units, P<0.001), in hypertensive patients (3.2+/-1.5 versus 4.4+/-2.2 units, P<0.001), and in smokers (3.0+/-1.5 versus 4.1+/-2.1 units, P=0.006). CONCLUSIONS: The Compliance Index was lower in patients with risk factors and was associated with poor exercise capacity. This index may be clinically useful for evaluating arterial stiffness.
Ju-Yi Chen; Wei-Chuan Tsai; Ming-Sheng Wu; Chih-Hsin Hsu; Chih-Chan Lin; Hsien-Tsai Wu; Li-Jen Lin; Jyh-Hong Chen
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  25     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1894-9     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
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MeSH Terms
Exercise Test*
Middle Aged
Plethysmography / methods

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