| Novel Biopolymer Matrices for Microencapsulation of Phages: Enhanced Protection Against Acidity and Protease Activity. | |
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MedLine Citation:
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PMID: 22847825 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Phage therapy by oral administration requires enhanced resistance of phages to the harsh gastric conditions. The aim of this work is the microencapsulation of phages in natural biopolymeric matrices as a protective barrier against the gastric environment. Alginate and pectin are used as base polymers. Further emulsification with oleic acid or coating with a different biopolymer is also studied. Emulsified pectin shows the maximum encapsulation efficiency and the highest protection against acidity, leaving more than 10(3) active phages after 30 min exposure at pH = 1.6, and protects phage from pepsin activity (4.2 mg mL(-1) ). Non-encapsulated phages are fully inactivated at pH = 1.6 or with pepsin (0.5 mg mL(-1) ) after 10 min. |
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Authors:
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Cecilia Dini; Germán A Islan; Patricio J de Urraza; Guillermo R Castro |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-30 |
Journal Detail:
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Title: Macromolecular bioscience Volume: - ISSN: 1616-5195 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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CIDCA (CONICET-UNLP) CCT La Plata, 1900, La Plata, Argentina; Cátedra de Microbiología, Facultad de Ciencias Exactas, UNLP., 1900, La Plata, Argentina. cdini@biol.unlp.edu.ar. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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