Document Detail

A Novel Approach to the Use of Doxycycline-Loaded Biodegradable Membrane and EDTA Root Surface Etching in Chronic Periodontitis: (A Randomized Clinical Trial).
MedLine Citation:
PMID:  22181689     Owner:  NLM     Status:  Publisher    
Background: The release profile of 25% Doxycycline gel loaded on a biodegradable collagen membrane after 24% EDTA root surface etching was evaluated. Method: Thirty systemically healthy patients each with at least one paired, contralateral interproximal intrabony defects (IBC) ≥4 mm deep, along with an interproximal probing depth (PD) ≥6mm and clinical attachment loss ≥4mm were randomized into two groups. G1 consisted of sites treated with open flap debridement followed by placement of doxycycline gel loaded collagen membrane (DOX-COL, G1), whereas G2 sites were treated with flap surgery followed by the placement of doxycycline gel loaded collagen membrane after EDTA etching of the exposed root surfaces (DOX-COL + EDTA, G2). Samples of gingival crevicular fluid were obtained 1, 3, 7, 14 and 21 days following surgery. Separation was performed and quantitative measurements of Doxycycline were taken with a high performance liquid chromatography. Clinical evaluation and follow-up for six months were performed. Results: At 21 days DOX-COL+ EDTA group showed 5.3 μg/ml value. However, no DOX was detected in samples of the DOX-COL. DOX-COL+ EDTA treated group retained more DOX during the periods of 3, 7, 10 and 14 days than did the DOX-COL group. Conclusion: EDTA root surface etching could enhance DOX availability in the GCF following its release from collagen membrane.
Ahmed Y Gamal; Radi M Kumper
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-19
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Faculty of Dental Medicine, Department of Periodontology, Al- Azhar University, Cairo, Egypt.
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