| A Novel Approach to the Use of Doxycycline-Loaded Biodegradable Membrane and EDTA Root Surface Etching in Chronic Periodontitis: (A Randomized Clinical Trial). | |
MedLine Citation:
|
PMID: 22181689 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: The release profile of 25% Doxycycline gel loaded on a biodegradable collagen membrane after 24% EDTA root surface etching was evaluated. Method: Thirty systemically healthy patients each with at least one paired, contralateral interproximal intrabony defects (IBC) ≥4 mm deep, along with an interproximal probing depth (PD) ≥6mm and clinical attachment loss ≥4mm were randomized into two groups. G1 consisted of sites treated with open flap debridement followed by placement of doxycycline gel loaded collagen membrane (DOX-COL, G1), whereas G2 sites were treated with flap surgery followed by the placement of doxycycline gel loaded collagen membrane after EDTA etching of the exposed root surfaces (DOX-COL + EDTA, G2). Samples of gingival crevicular fluid were obtained 1, 3, 7, 14 and 21 days following surgery. Separation was performed and quantitative measurements of Doxycycline were taken with a high performance liquid chromatography. Clinical evaluation and follow-up for six months were performed. Results: At 21 days DOX-COL+ EDTA group showed 5.3 μg/ml value. However, no DOX was detected in samples of the DOX-COL. DOX-COL+ EDTA treated group retained more DOX during the periods of 3, 7, 10 and 14 days than did the DOX-COL group. Conclusion: EDTA root surface etching could enhance DOX availability in the GCF following its release from collagen membrane. |
Authors:
|
Ahmed Y Gamal; Radi M Kumper |
Related Documents
:
|
12904269 - Risk of whole body radiation exposure and protective measures in fluoroscopically guide... 24511809 - An audit of the cost effectiveness of protocol-driven versus surgeon-directed pre-opera... 21740159 - Relaxin does not rescue coronal suture fusion in craniosynostotic rabbits. 23119849 - Ligation vs. bipolar diathermy for haemostasis in tonsillectomy-a comparative study. 25100489 - Effect of a novel sterilization method on biomechanical properties of soft tissue allog... 21926869 - Simultaneous open reduction of ipsilateral congenital dislocation of the hip and knee a... 24602079 - Atrial arrhythmias following surgical af ablation: electrophysiological findings, ablat... 23022759 - Perioperative pai-1 values in surgically treated colorectal carcinoma patients under lo... 10367869 - Prophylactic antibiotics for elective laparoscopic cholecystectomy: are they necessary? |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
|
Title: Journal of periodontology Volume: - ISSN: 1943-3670 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the Faculty of Dental Medicine, Department of Periodontology, Al- Azhar University, Cairo, Egypt. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship Between Serum Albumin Concentration and Periodontal Condition in Head and Neck Cancer P...
Next Document: Global myocardial function is compromised in infants with pulmonary hypertension.