| A Novel Approach to the Use of Doxycycline-Loaded Biodegradable Membrane and EDTA Root Surface Etching in Chronic Periodontitis: (A Randomized Clinical Trial). | |
MedLine Citation:
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PMID: 22181689 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The release profile of 25% Doxycycline gel loaded on a biodegradable collagen membrane after 24% EDTA root surface etching was evaluated. Method: Thirty systemically healthy patients each with at least one paired, contralateral interproximal intrabony defects (IBC) ≥4 mm deep, along with an interproximal probing depth (PD) ≥6mm and clinical attachment loss ≥4mm were randomized into two groups. G1 consisted of sites treated with open flap debridement followed by placement of doxycycline gel loaded collagen membrane (DOX-COL, G1), whereas G2 sites were treated with flap surgery followed by the placement of doxycycline gel loaded collagen membrane after EDTA etching of the exposed root surfaces (DOX-COL + EDTA, G2). Samples of gingival crevicular fluid were obtained 1, 3, 7, 14 and 21 days following surgery. Separation was performed and quantitative measurements of Doxycycline were taken with a high performance liquid chromatography. Clinical evaluation and follow-up for six months were performed. Results: At 21 days DOX-COL+ EDTA group showed 5.3 μg/ml value. However, no DOX was detected in samples of the DOX-COL. DOX-COL+ EDTA treated group retained more DOX during the periods of 3, 7, 10 and 14 days than did the DOX-COL group. Conclusion: EDTA root surface etching could enhance DOX availability in the GCF following its release from collagen membrane. |
Authors:
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Ahmed Y Gamal; Radi M Kumper |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: Journal of periodontology Volume: - ISSN: 1943-3670 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Faculty of Dental Medicine, Department of Periodontology, Al- Azhar University, Cairo, Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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