| Novel applications of Dermabond (2-octyl -cyanoacrylate) in cardiothoracic surgery. | |
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MedLine Citation:
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PMID: 17429768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dermabond (Ethicon Inc., Somerville, NJ, USA) is a cyanoacrylate adhesive normally indicated for skin wound closure. This study describes the emergency use of this adhesive to control bleeding close to coronary anastomoses in exceptional cases. Dermabond was used in 17 patients who underwent cardiac surgery during an eight-month period, where other haemostatic interventions were unsuitable. It was applied for haemorrhage in 15 patients and control air leaks in two of the patients. Haemostasis was successful with Dermabond alone in 11 patients; the remaining four required additional interventions. It effectively controlled haemorrhage from ventricular pacing wires, vascular sling holes, peri-anastomotic bleeding, and epicardial tears. The adhesive was not placed directly on any graft because of embolic risk. In the two patients with visible air leaks, it was successfully used. No patient events were recorded as a result of haemorrhage and no reported toxicity. Dermabond may be indicated in circumstances in which haemostasis with traditional methods has failed or is inappropriate. A need for further high-quality objective research exists on the effectiveness and long-term safety of 2-octyl cyanoacrylate in cardiac surgery. |
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Authors:
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Omer Aziz; M S Rahman; V G Hadjianastassiou; John Kokotsakis; Malinovski Vitali; Ashok Cherian; Ara Darzi; Thanos Athanasiou |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Surgical technology international Volume: 16 ISSN: 1090-3941 ISO Abbreviation: Surg Technol Int Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-12 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9604509 Medline TA: Surg Technol Int Country: United States |
Other Details:
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Languages: eng Pagination: 46-51 Citation Subset: IM |
Affiliation:
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Department of Biosurgery & Surgical Technology, St. Mary's Hospital, Imperial College, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular Surgical Procedures
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adverse effects*,
methods Cyanoacrylates / therapeutic use* Humans Postoperative Hemorrhage / etiology*, prevention & control* Thoracic Surgical Procedures / adverse effects*, methods Tissue Adhesives / therapeutic use* Treatment Outcome Wound Healing / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cyanoacrylates; 0/Tissue Adhesives; 6701-17-3/octyl 2-cyanoacrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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