Document Detail

Novel applications of Dermabond (2-octyl -cyanoacrylate) in cardiothoracic surgery.
MedLine Citation:
PMID:  17429768     Owner:  NLM     Status:  MEDLINE    
Dermabond (Ethicon Inc., Somerville, NJ, USA) is a cyanoacrylate adhesive normally indicated for skin wound closure. This study describes the emergency use of this adhesive to control bleeding close to coronary anastomoses in exceptional cases. Dermabond was used in 17 patients who underwent cardiac surgery during an eight-month period, where other haemostatic interventions were unsuitable. It was applied for haemorrhage in 15 patients and control air leaks in two of the patients. Haemostasis was successful with Dermabond alone in 11 patients; the remaining four required additional interventions. It effectively controlled haemorrhage from ventricular pacing wires, vascular sling holes, peri-anastomotic bleeding, and epicardial tears. The adhesive was not placed directly on any graft because of embolic risk. In the two patients with visible air leaks, it was successfully used. No patient events were recorded as a result of haemorrhage and no reported toxicity. Dermabond may be indicated in circumstances in which haemostasis with traditional methods has failed or is inappropriate. A need for further high-quality objective research exists on the effectiveness and long-term safety of 2-octyl cyanoacrylate in cardiac surgery.
Omer Aziz; M S Rahman; V G Hadjianastassiou; John Kokotsakis; Malinovski Vitali; Ashok Cherian; Ara Darzi; Thanos Athanasiou
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Surgical technology international     Volume:  16     ISSN:  1090-3941     ISO Abbreviation:  Surg Technol Int     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-12     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9604509     Medline TA:  Surg Technol Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46-51     Citation Subset:  IM    
Department of Biosurgery & Surgical Technology, St. Mary's Hospital, Imperial College, London, UK.
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MeSH Terms
Cardiovascular Surgical Procedures / adverse effects*,  methods
Cyanoacrylates / therapeutic use*
Postoperative Hemorrhage / etiology*,  prevention & control*
Thoracic Surgical Procedures / adverse effects*,  methods
Tissue Adhesives / therapeutic use*
Treatment Outcome
Wound Healing / drug effects
Reg. No./Substance:
0/Cyanoacrylates; 0/Tissue Adhesives; 6701-17-3/octyl 2-cyanoacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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