Document Detail


A Novel Angiotensin Converting Enzyme Inhibitory Peptide Derived from Proteolytic Digest of Chinese Soft-Shelled Turtle Egg White Proteins.
MedLine Citation:
PMID:  24140975     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BIOLOGICAL SIGNIFICANCE: Inhibition of ACE has proven to be an effective strategy in prevention and treatment of hypertension and related diseases. Unlike typical synthetic ACE inhibitors which exert well described side effects, food-derived peptides with ACE inhibitory activity may be safer alternatives for hypertension treatment. In this study, we comprehensively identified peptides derived from SSTEW digest using proteomics approach. IW-11, which is derived from lysozyme, the most abundant protein in SSTEW, showed remarkable inhibition towards ACE. This peptide has been demonstrated a competitive inhibitory property which is able to bind to ACE active site and found to be a true inhibitor against ACE according to Lineweaver-Burk plots. Using an optimized thermolysin condition, IW-11 can be readily obtained without any complex purification step, which will benefit its further application to prevention or treatment of hypertension.
Authors:
Reynetha D S Rawendra; Aisha; Chi-I Chang; Aulanni'am; Ho-Hsien Chen; Tzou-Chi Huang; Jue-Liang Hsu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-16
Journal Detail:
Title:  Journal of proteomics     Volume:  -     ISSN:  1876-7737     ISO Abbreviation:  J Proteomics     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101475056     Medline TA:  J Proteomics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013.
Affiliation:
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, Taiwan; Department of Food Science, National Pingtung University of Science and Technology, 912 Pingtung, Taiwan; Department of Food Science, Faculty of Agricultural Technology, University of Brawijaya, Malang, Indonesia.
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