| Novel 3' ends that support translation. | |
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MedLine Citation:
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PMID: 23154978 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The 3' ends of two large noncoding RNAs, MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) and MEN β, are formed by cleavage by RNase P and are capped but not polyadenylated. In the November 1, 2012, issue of Genes & Development, Wilusz and colleagues (pp. 2392-2407) show that when these 3' ends are formed on a GFP reporter, the resulting mRNA is exported to the cytoplasm and translated. The 3' end forms a novel triple-helical structure that supports export and translation as well as a poly(A) tail does. |
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Authors:
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William F Marzluff |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Genes & development Volume: 26 ISSN: 1549-5477 ISO Abbreviation: Genes Dev. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-16 Completed Date: 2013-01-17 Revised Date: 2013-05-15 |
Medline Journal Info:
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Nlm Unique ID: 8711660 Medline TA: Genes Dev Country: United States |
Other Details:
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Languages: eng Pagination: 2457-60 Citation Subset: - |
Affiliation:
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Program in Molecular Biology, Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA. marzluff@med.unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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GM29832/GM/NIGMS NIH HHS |
| Comments/Corrections | |
Comment On:
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Cell. 2008 Nov 28;135(5):919-32
[PMID:
19041754
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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