Document Detail


Novel 3' ends that support translation.
MedLine Citation:
PMID:  23154978     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The 3' ends of two large noncoding RNAs, MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) and MEN β, are formed by cleavage by RNase P and are capped but not polyadenylated. In the November 1, 2012, issue of Genes & Development, Wilusz and colleagues (pp. 2392-2407) show that when these 3' ends are formed on a GFP reporter, the resulting mRNA is exported to the cytoplasm and translated. The 3' end forms a novel triple-helical structure that supports export and translation as well as a poly(A) tail does.
Authors:
William F Marzluff
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Genes & development     Volume:  26     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-01-17     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2457-60     Citation Subset:  -    
Affiliation:
Program in Molecular Biology, Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA. marzluff@med.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
GM29832/GM/NIGMS NIH HHS
Comments/Corrections
Comment On:
Cell. 2008 Nov 28;135(5):919-32   [PMID:  19041754 ]

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