| Novel 3-O-glycosyl-3-demethylthiocolchicines as ligands for glycine and gamma-aminobutyric acid receptors. | |
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MedLine Citation:
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PMID: 17411024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on gamma-aminobutyric acid (GABA) and strychnine-sensitive glycine receptors present in rat brain and spinal cord. Two different synthetic approaches were used with the readily available 3-O-demethylthiocolchicine (1b) and thiocolchicoside (2a). Glycosyl compounds 2a-g were obtained from 1b and 1-fluorosugars 4. 6'-Heterosubstituted glycosyl compounds 6-12 and the 6'-desoxy derivative 2h were prepared from 2a. |
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Authors:
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Maria Luisa Gelmi; Gabriele Fontana; Donato Pocar; Guido Pontremoli; Sara Pellegrino; Ezio Bombardelli; Antonella Riva; Walter Balduini; Silvia Carloni; Mauro Cimino |
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Publication Detail:
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Type: In Vitro; Journal Article Date: 2007-04-06 |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 50 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-26 Completed Date: 2007-06-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: United States |
Other Details:
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Languages: eng Pagination: 2245-8 Citation Subset: IM |
Affiliation:
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Istituto di Chimica Organica "A. Marchesini", Facoltà di Farmacia, Università di Milano, Via Venezian 21, 20133 Milano, Italy. marialuisa.gelmi@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Binding Sites Brain / metabolism Colchicine / analogs & derivatives*, chemical synthesis*, pharmacology Glycosides / chemical synthesis*, pharmacology Ligands Muscimol / pharmacology Radioligand Assay Rats Rats, Sprague-Dawley Receptors, GABA / metabolism* Receptors, Glycine / metabolism* Spinal Cord / metabolism Structure-Activity Relationship Strychnine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Glycosides; 0/Ligands; 0/Receptors, GABA; 0/Receptors, Glycine; 2763-96-4/Muscimol; 57-24-9/Strychnine; 64-86-8/Colchicine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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