| Novel 1,2,5-oxadiazine derivatives--synthesis and in vitro biological studies. | |
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MedLine Citation:
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PMID: 14769241 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new synthetic approach to the 1,2,5-oxadiazine ring system is described. 2-Substituted or 2,4-disubstituted 2H-1,2,5-oxadiazine-3,6(4H,5H)-dione derivatives 4 were prepared by cyclisation of hydroxamic acids 3 derived from N-(1-benzotriazolylcarbonyl)-amino acids 1. The structures of the synthesised compounds were fully characterised by IR, 1H and 13C NMR spectroscopy and elemental analysis. The aim of this study was to evaluate biological activity of the newly synthesised oxadiazine derivatives. Cytotoxic and cytostatic activities were tested on two cell lines (HeLa and GMK) and evaluated by MTT-test. Two human DNA viruses (adenovirus 7 and herpesvirus 1) and two human RNA viruses (coxsackievirus B5 and echovirus 7) were used in the antiviral test. Selected biological studies indicated that 2-phenyl- -2H-1,2,5-oxadiazine-3,6(4H,5H)-dione (4a) and 4-benzyl-2-phenyl-2H-1,2,5-oxadiazine-3,6(4H,5H)-dione (4c) statistically significantly inhibited cell growth. A minor antiviral effect was observed upon adenovirus, herpesvirus and enteroviruses. |
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Authors:
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Monika Barbarić; Sandra Kraljević; Magdalena Grce; Branka Zorc |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta pharmaceutica (Zagreb, Croatia) Volume: 53 ISSN: 1330-0075 ISO Abbreviation: Acta Pharm Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2004-02-10 Completed Date: 2004-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9303678 Medline TA: Acta Pharm Country: Croatia |
Other Details:
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Languages: eng Pagination: 175-86 Citation Subset: IM |
Affiliation:
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Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. mlovrek@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiviral Agents / chemical synthesis, pharmacology Cercopithecus aethiops Hela Cells Humans Oxadiazoles / chemical synthesis*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Oxadiazoles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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