Document Detail

The Novacode criteria for classification of ECG abnormalities and their clinically significant progression and regression.
MedLine Citation:
PMID:  9682893     Owner:  NLM     Status:  MEDLINE    
Electrocardiographic (ECG) manifestations of clinical and subclinical cardiovascular disease are used as an important component in the evaluation of clinical trials, and there is an increasing demand for well-defined criteria for clinically significant evolution of ECG abnormalities. The Novacode ECG classification system provides a comprehensive hierarchical set of criteria for prevalent ECG abnormalities and for clinically significant serial ECG changes, both adverse and favorable, as a response to pharmacologic, surgical, and other interventions. These criteria are used to grade Q wave and ischemic abnormalities in order to achieve stable classification of both prevalent and incident myocardial infarctions by minimizing false classifications due to clinically insignificant ECG variations. This approach differs from the traditional Minnesota Code classification system, in which incident events are determined by changes in classification categories, with the application of additional elaborate validation rules to exclude frequent false classifications. Novacode hierarchy is so structured that for each abnormality, a general class is first determined with the simplest possible classification criteria and more specific abnormality subgroups are then classified with more elaborate criteria. This approach will satisfy differing needs of clinical trials for detail in classification. Explicit definition of ECG variables and condition statements for the classification criteria facilitate implementation of the Novacode with computer ECG programs.
P M Rautaharju; L P Park; B R Chaitman; F Rautaharju; Z M Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  31     ISSN:  0022-0736     ISO Abbreviation:  J Electrocardiol     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-09-17     Completed Date:  1998-09-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-87     Citation Subset:  IM    
Epidemiological Cardiology Research Center (EPICARE), the Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27104, USA.
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MeSH Terms
Arrhythmias, Cardiac / diagnosis
Cardiomegaly / diagnosis
Electrocardiography / classification*
Myocardial Infarction / diagnosis
Risk Factors
Comment In:
J Electrocardiol. 2000 Apr;33(2):203   [PMID:  10819415 ]

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