| Notch1 Expression is an Independent Predictor of Prognosis in Colorectal Cancer, Which is Related to p65 Status. | |
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MedLine Citation:
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PMID: 21771876 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Notch1 has been proved to be aberrantly expressed in colorectal cancer and related to tumor differentiation status. However, few previous studies concentrated on the predictive role of Notch1 expression on the overall survival of patients with colorectal cancer. This study explored expression of Notch1 and its relationship with p65 and prognosis in colorectal cancer.EXPERIMENTAL DESIGN: Two independent study cohorts were involved in the present study. Clinical specimens from 941 eligible patients were constructed into tissue microarrays. The expression of Notch1 and p65 protein was investigated by immunohistochemistry. RESULTS: Statistically significant positive correlations were found between protein expression of Notch1 and p65 in both retrospective and prospective study cohort. Patients with higher Notch1 expression showed a trend to have shorter survival time, whereas patients with lower Notch1 expression had better survival in both study cohorts. In multivariate analysis, Notch1 expression was proved to be an independent predictor of prognosis. Moreover, the prognostic value of Notch1 might differ according to p65 status.CONCLUSIONS: Notch1 is an independent predictor of prognosis for patients with colorectal cancer. In addition, the predictive role of Notch1 on clinical outcome might be modified by p65 status, suggesting that targeting Notch1 and NF-κB might be a promising strategy for colorectal cancer treatment. |
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Authors:
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Dake Chu; Yi Zhou; Zixi Zhang; Yunming Li; Jipeng Li; Jianyong Zheng; Hong Wei Zhang; Qingchuan Zhao; Weizhong Wang; Rui'an Wang; Gang Ji |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-19 |
Journal Detail:
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Title: Clinical cancer research : an official journal of the American Association for Cancer Research Volume: - ISSN: 1078-0432 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502500 Medline TA: Clin Cancer Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Gastrointestinal Surgery, Xijing Hospital, State Key Laboratory of Cancer Biology, The Fourth Military Medical University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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