Document Detail

Notch signalling and the synchronization of the somite segmentation clock.
MedLine Citation:
PMID:  11100729     Owner:  NLM     Status:  MEDLINE    
In vertebrates with mutations in the Notch cell-cell communication pathway, segmentation fails: the boundaries demarcating somites, the segments of the embryonic body axis, are absent or irregular. This phenotype has prompted many investigations, but the role of Notch signalling in somitogenesis remains mysterious. Somite patterning is thought to be governed by a "clock-and-wavefront" mechanism: a biochemical oscillator (the segmentation clock) operates in the cells of the presomitic mesoderm, the immature tissue from which the somites are sequentially produced, and a wavefront of maturation sweeps back through this tissue, arresting oscillation and initiating somite differentiation. Cells arrested in different phases of their cycle express different genes, defining the spatially periodic pattern of somites and controlling the physical process of segmentation. Notch signalling, one might think, must be necessary for oscillation, or to organize subsequent events that create the somite boundaries. Here we analyse a set of zebrafish mutants and arrive at a different interpretation: the essential function of Notch signalling in somite segmentation is to keep the oscillations of neighbouring presomitic mesoderm cells synchronized.
Y J Jiang; B L Aerne; L Smithers; C Haddon; D Ish-Horowicz; J Lewis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  408     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-01     Completed Date:  2000-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  475-9     Citation Subset:  IM    
Vertebrate Development Laboratory, Imperial Cancer Research Fund, London, UK.
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MeSH Terms
Body Patterning / genetics,  physiology*
Embryo, Nonmammalian / cytology,  physiology
Embryonic Development
Membrane Proteins / biosynthesis,  physiology*
Mesoderm / physiology
Receptors, Notch
Signal Transduction*
Somites / physiology
Reg. No./Substance:
0/Ligands; 0/Membrane Proteins; 0/Receptors, Notch; 0/delta protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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