Document Detail

Notch signaling is required for arterial-venous differentiation during embryonic vascular development.
MedLine Citation:
PMID:  11585794     Owner:  NLM     Status:  MEDLINE    
Recent evidence indicates that acquisition of artery or vein identity during vascular development is governed, in part, by genetic mechanisms. The artery-specific expression of a number of Notch signaling genes in mouse and zebrafish suggests that this pathway may play a role in arterial-venous cell fate determination during vascular development. We show that loss of Notch signaling in zebrafish embryos leads to molecular defects in arterial-venous differentiation, including loss of artery-specific markers and ectopic expression of venous markers within the dorsal aorta. Conversely, we find that ectopic activation of Notch signaling leads to repression of venous cell fate. Finally, embryos lacking Notch function exhibit defects in blood vessel formation similar to those associated with improper arterial-venous specification. Our results suggest that Notch signaling is required for the proper development of arterial and venous blood vessels, and that a major role of Notch signaling in blood vessels is to repress venous differentiation within developing arteries. Movies available on-line
N D Lawson; N Scheer; V N Pham; C H Kim; A B Chitnis; J A Campos-Ortega; B M Weinstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  128     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-04     Completed Date:  2001-12-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3675-83     Citation Subset:  IM    
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA.
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MeSH Terms
Arteries / embryology*
Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Biological Markers
Cell Differentiation / physiology
Embryonic Induction*
Gene Expression Regulation, Developmental
Membrane Proteins / genetics,  metabolism
Molecular Sequence Data
Proteins / metabolism
Proto-Oncogene Proteins / genetics,  metabolism*
Receptor Protein-Tyrosine Kinases / metabolism
Receptors, Cell Surface*
Receptors, Growth Factor / metabolism
Signal Transduction
Vascular Endothelial Growth Factor Receptor-3
Veins / embryology*
Zebrafish / embryology*,  genetics
Zebrafish Proteins*
Grant Support
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/Biological Markers; 0/Ephrin-B2; 0/Membrane Proteins; 0/Proteins; 0/Proto-Oncogene Proteins; 0/Receptors, Cell Surface; 0/Receptors, Growth Factor; 0/Zebrafish Proteins; 0/delta protein; 0/hey2 protein, zebrafish; EC Protein-Tyrosine Kinases; EC Endothelial Growth Factor Receptor-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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