Document Detail


Notch signaling in intestinal homeostasis across species: the cases of Drosophila, Zebrafish and the mouse.
MedLine Citation:
PMID:  21745469     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Notch signaling has been recently shown to have a fundamental role in stem cell maintenance and control of proper homeostasis in the intestine of different species. Here, we briefly review the current literature on Notch signals in the intestine of Drosophila, Zebrafish and the mouse, and try to highlight conserved and divergent Notch functions across species. Notch signals show a remarkably conserved role in skewing cell fate choices in intestinal lineages throughout evolution. Genetic analysis demonstrates that loss of Notch signaling invariably leads to increased numbers of secretory cells and loss of enterocytes, while gain of Notch function will completely block secretory cell differentiation. Finally, we discuss the potential contribution of Notch signaling to the initiation of colorectal cancer by controlling the maintenance of the undifferentiated state of intestinal neoplastic cells and speculate on the therapeutic consequences of affecting cancer stem cells.
Authors:
Silvia Fre; Allison Bardin; Sylvie Robine; Daniel Louvard
Related Documents :
8899309 - Influence of ukrain on dna, rna and protein synthesis in malignant cells.
7477879 - Hemodynamic regulation of tyrosine hydroxylase messenger rna in medullary catecholamine...
21274459 - Antimetastatic potentials of dioscorea nipponica on melanoma in vitro and in vivo.
1581359 - Posttranslational regulation of spermidine/spermine n1-acetyltransferase with stress.
21533439 - Gender influences tumour growth in a model of human oral squamous cell carcinoma.
15002659 - Uptake of polyamines by the unicellular green alga chlamydomonas reinhardtii and their ...
21457619 - Viability, morphology and function of primary endothelial cells on poly(n-butyl acrylat...
18465069 - Atrazine exposure decreases cell proliferation in chinese hamster ovary (cho-k1) cell l...
15489899 - Regulation of the cyclin a1 protein is associated with its differential subcellular loc...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-30
Journal Detail:
Title:  Experimental cell research     Volume:  -     ISSN:  1090-2422     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Morphogenesis and Intracellular Signaling, Institut Curie, UMR 144 CNRS, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  LAMMER kinase Kic1 is involved in pre-mRNA processing.
Next Document:  Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-clo...