| Notch signaling in the immune system. | |
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MedLine Citation:
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PMID: 20152168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Notch signaling pathway regulates many aspects of embryonic development, as well as differentiation processes and tissue homeostasis in multiple adult organ systems. Disregulation of Notch signaling is associated with several human disorders, including cancer. In the last decade, it became evident that Notch signaling plays important roles within the hematopoietic and immune systems. Notch plays an essential role in the development of embryonic hematopoietic stem cells and influences multiple lineage decisions of developing lymphoid and myeloid cells. Moreover, recent evidence suggests that Notch is an important modulator of T cell-mediated immune responses. In this review, we discuss Notch signaling in hematopoiesis, lymphocyte development, and function as well as in T cell acute lymphoblastic leukemia. |
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Authors:
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Freddy Radtke; Nicolas Fasnacht; H Robson Macdonald |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Immunity Volume: 32 ISSN: 1097-4180 ISO Abbreviation: Immunity Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
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Languages: eng Pagination: 14-27 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Ecole Polytechnique F?d?rale de Lausanne (EPFL), Swiss Institute for Experimental Cancer Research (ISREC), Station 19, 1015 Lausanne, Switzerland. freddy.radtke@epfl.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocytes / cytology, immunology Cell Differentiation / immunology Humans Leukemia-Lymphoma, Adult T-Cell / immunology Receptors, Notch / immunology* Signal Transduction / immunology* T-Lymphocytes / cytology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Notch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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