Document Detail


Notch receptor-ligand binding and activation: insights from molecular studies.
MedLine Citation:
PMID:  22326375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Notch receptor is part of a core signalling pathway which is highly conserved in all metazoan species. It is required for various cell fate decisions at multiple stages of development and in the adult organism, with dysregulation of the pathway associated with genetic and acquired diseases including cancer. Although cellular and in vivo studies have provided considerable insight into the downstream consequences of Notch signalling, relatively little is known about the molecular basis of the receptor/ligand interaction and initial stages of activation. Recent advances in structure determination of the extracellular regions of human Notch-1 and one of its ligands Jagged-1 have given new insights into docking events occurring at the cell surface which may facilitate the development of new highly specific therapies. We review the structural data available for receptor and ligands and identify the challenges ahead.
Authors:
Chandramouli R Chillakuri; Devon Sheppard; Susan M Lea; Penny A Handford
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-02-04
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  23     ISSN:  1096-3634     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-10-02     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  421-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Motifs
Animals
Binding Sites
Calcium-Binding Proteins / chemistry,  genetics
Cell Communication
Humans
Intercellular Signaling Peptides and Proteins / chemistry,  genetics
Membrane Proteins / chemistry,  genetics
Mutation
Protein Binding
Protein Structure, Tertiary
Receptors, Notch / chemistry*,  genetics
Signal Transduction
Grant Support
ID/Acronym/Agency:
087928//Wellcome Trust
Chemical
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Receptors, Notch; 134324-36-0/Serrate proteins
Comments/Corrections

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