Document Detail

Notch mediates Wnt and BMP signals in the early separation of smooth muscle progenitors and blood/endothelial common progenitors.
MedLine Citation:
PMID:  19168675     Owner:  NLM     Status:  MEDLINE    
During embryonic development in amniotes, the extraembryonic mesoderm, where the earliest hematopoiesis and vasculogenesis take place, also generates smooth muscle cells (SMCs). It is not well understood how the differentiation of SMCs is linked to that of blood (BCs) and endothelial (ECs) cells. Here we show that, in the chick embryo, the SMC lineage is marked by the expression of a bHLH transcription factor, dHand. Notch activity in nascent ventral mesoderm cells promotes SMC progenitor formation and mediates the separation of SMC and BC/EC common progenitors marked by another bHLH factor, Scl. This is achieved by crosstalk with the BMP and Wnt pathways, which are involved in mesoderm ventralization and SMC lineage induction, respectively. Our findings reveal a novel role of the Notch pathway in early ventral mesoderm differentiation, and suggest a stepwise separation among its three main lineages, first between SMC progenitors and BC/EC common progenitors, and then between BCs and ECs.
Masahiro Shin; Hiroki Nagai; Guojun Sheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  136     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  595-603     Citation Subset:  IM    
RIKEN Center for Developmental Biology, Laboratory for Early Embryogenesis, Kobe, Hyogo 650-0047, Japan.
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MeSH Terms
Avian Proteins / metabolism
Basic Helix-Loop-Helix Transcription Factors / metabolism
Biological Markers / metabolism
Blood Cells / cytology*,  metabolism
Bone Morphogenetic Proteins / metabolism*
Cell Differentiation
Cell Lineage
Endothelial Cells / cytology*,  metabolism
Mesoderm / cytology,  embryology,  metabolism
Models, Biological
Myocytes, Smooth Muscle / cytology*,  metabolism
Receptors, Notch / metabolism*
Signal Transduction*
Stem Cells / cytology,  metabolism
Wnt Proteins / metabolism*
Reg. No./Substance:
0/Avian Proteins; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Biological Markers; 0/Bone Morphogenetic Proteins; 0/Receptors, Notch; 0/Wnt Proteins

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