| Notch in the kidney: development and disease. | |
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MedLine Citation:
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PMID: 21952830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Notch signalling is a highly conserved cell-cell communication mechanism that regulates development, tissue homeostasis, and repair. Within the kidney, Notch has an important function in orchestrating kidney development. Recent studies indicate that Notch plays a key role in establishing proximal epithelial fate during nephron segmentation as well as the differentiation of principal cells in the renal collecting system. Notch signalling is markedly reduced in the adult kidney; however, increased Notch signalling has been noted in both acute and chronic kidney injury. Increased glomerular epithelial Notch signalling has been associated with albuminuria and glomerulosclerosis, while tubular epithelial Notch activation caused fibrosis development most likely inducing an improper epithelial repair pathway. Recent studies thereby indicate that Notch is a key regulator of kidney development, repair, and injury. |
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Authors:
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Yasemin Sirin; Katalin Susztak |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-08-24 |
Journal Detail:
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Title: The Journal of pathology Volume: 226 ISSN: 1096-9896 ISO Abbreviation: J. Pathol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-01 Completed Date: 2012-01-18 Revised Date: 2013-06-12 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: England |
Other Details:
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Languages: eng Pagination: 394-403 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Department of Nephrology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Renal Cell / genetics, physiopathology, therapy Cell Communication / physiology Chronic Disease Disease Models, Animal Fibrosis / genetics, pathology Humans Kidney / embryology*, physiology Kidney Diseases / genetics, physiopathology*, therapy Kidney Neoplasms / genetics, physiopathology, therapy Mutation / genetics Receptors, Notch / antagonists & inhibitors, genetics, physiology* Regeneration / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK076077/DK/NIDDK NIH HHS; R01DK076077/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Notch |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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