Document Detail


Notch in the kidney: development and disease.
MedLine Citation:
PMID:  21952830     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Notch signalling is a highly conserved cell-cell communication mechanism that regulates development, tissue homeostasis, and repair. Within the kidney, Notch has an important function in orchestrating kidney development. Recent studies indicate that Notch plays a key role in establishing proximal epithelial fate during nephron segmentation as well as the differentiation of principal cells in the renal collecting system. Notch signalling is markedly reduced in the adult kidney; however, increased Notch signalling has been noted in both acute and chronic kidney injury. Increased glomerular epithelial Notch signalling has been associated with albuminuria and glomerulosclerosis, while tubular epithelial Notch activation caused fibrosis development most likely inducing an improper epithelial repair pathway. Recent studies thereby indicate that Notch is a key regulator of kidney development, repair, and injury.
Authors:
Yasemin Sirin; Katalin Susztak
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-08-24
Journal Detail:
Title:  The Journal of pathology     Volume:  226     ISSN:  1096-9896     ISO Abbreviation:  J. Pathol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-01     Completed Date:  2012-01-18     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  394-403     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Affiliation:
Department of Nephrology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Renal Cell / genetics,  physiopathology,  therapy
Cell Communication / physiology
Chronic Disease
Disease Models, Animal
Fibrosis / genetics,  pathology
Humans
Kidney / embryology*,  physiology
Kidney Diseases / genetics,  physiopathology*,  therapy
Kidney Neoplasms / genetics,  physiopathology,  therapy
Mutation / genetics
Receptors, Notch / antagonists & inhibitors,  genetics,  physiology*
Regeneration / physiology
Grant Support
ID/Acronym/Agency:
R01 DK076077/DK/NIDDK NIH HHS; R01DK076077/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Notch
Comments/Corrections

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