Document Detail

Notch activity in neural progenitors coordinates cytokinesis and asymmetric differentiation.
MedLine Citation:
PMID:  25336612     Owner:  NLM     Status:  Publisher    
Asymmetric division of neural progenitor cells is a crucial event in the generation of neuronal diversity and involves the segregation of distinct proteins into daughter cells, thereby promoting unique differentiation programs. Although it was known that Notch signaling acts postmitotically to orchestrate differentiation of daughter cells from asymmetrically dividing precursor cells, Bhat reported a previously uncharacterized role for Notch that occurs before cell division to promote the asymmetric localization of the protein Numb and the positioning of the cleavage furrow. Numb is an inhibitor of Notch activity; thus, this mechanism forms a regulatory feedback loop to control asymmetric cytokinesis and differentiation.
Filipe Pinto-Teixeira; Claude Desplan
Publication Detail:
Type:  REVIEW     Date:  2014-10-21
Journal Detail:
Title:  Science signaling     Volume:  7     ISSN:  1937-9145     ISO Abbreviation:  Sci Signal     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-22     Completed Date:  -     Revised Date:  2014-10-23    
Medline Journal Info:
Nlm Unique ID:  101465400     Medline TA:  Sci Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  pe26     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Association for the Advancement of Science.
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