| Notch Signaling During Human T cell Development. | |
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MedLine Citation:
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PMID: 22692833 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species. Here, we review our current understanding of how Notch signaling is activated and used during human T cell development. First, we set the stage by describing the developmental steps that make up human T cell development before describing the expression profiles of Notch receptors, ligands, and target genes during this process. To delineate stage-specific roles for Notch signaling during human T cell development, we subsequently try to interpret the functional Notch studies that have been performed in light of these expression profiles and compare this to its suggested role in the mouse. |
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Authors:
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Tom Taghon; Els Waegemans; Inge Van de Walle |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-14 |
Journal Detail:
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Title: Current topics in microbiology and immunology Volume: - ISSN: 0070-217X ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0110513 Medline TA: Curr Top Microbiol Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, 9000, Ghent, Belgium, tom.taghon@ugent.be. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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