| Not your father's planarian: a classic model enters the era of functional genomics. | |
| | |
MedLine Citation:
|
PMID: 11972158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Freshwater planarians were a classic model for studying the problems of development and regeneration. However, as attention shifted towards animals with more rigid developmental processes, the planarians, with their notoriously plastic ontogeny, declined in significance as a model system. This trend was exacerbated with the introduction of genetic and molecular approaches, which did not work well in planarians. More recently, the heightened interest in stem-cell biology, along with the successful application of molecular, cellular and genomic approaches in planarians, is re-establishing these fascinating organisms as models for studying regeneration and developmental plasticity. |
| | |
Authors:
|
Philip A Newmark; Alejandro Sánchez Alvarado |
Related Documents
:
|
19802608 - Modeling multiple sclerosis in laboratory animals. 16398978 - Reliability of rodent animal models in biomedical research. 9548668 - A new model for pancreatitis. 16938138 - A tool for exploring space-time patterns: an animation user research. 21587108 - The quantitative assessment of risk factors to overstress at adjacent segments after lu... 12045458 - A limited-sampling strategy to estimate individual pharmacokinetic parameters of vinore... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Nature reviews. Genetics Volume: 3 ISSN: 1471-0056 ISO Abbreviation: Nat. Rev. Genet. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-04-24 Completed Date: 2002-05-10 Revised Date: 2010-09-02 |
Medline Journal Info:
|
Nlm Unique ID: 100962779 Medline TA: Nat Rev Genet Country: England |
Other Details:
|
Languages: eng Pagination: 210-9 Citation Subset: IM |
Affiliation:
|
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, 601 S. Goodwin Avenue, Urbana, Illinois 61801, USA. pnewmark@life.uiuc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Female Genomics Male Models, Genetic* Planarians / genetics*, growth & development, physiology Regeneration Reproduction Stem Cells / cytology |
| Grant Support | |
ID/Acronym/Agency:
|
F32 GM019539-02S1/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Getting under the skin of epidermal morphogenesis.
Next Document: Science and society: children and incompetent adults in genetic research: consent and safeguards.