Document Detail


Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries.
MedLine Citation:
PMID:  15588737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
P-450 metabolites, including the epoxyeicosatrienoic acids, are likely candidates for endothelial derived hyperpolarising factor (EDHF). In the present study, we confirm that the stable analogue 11-nonyloxyundec-8(Z)-enoic acid is a vasodilator of murine vessels. However, we also show that the 'epoxyeicosatrienoic acid receptor' antagonist 14,15 EEZE similarly dilates murine vessels contracted with U46619, prostaglandin F2alpha or methoxamine, but not with endothelin-1 or potassium. We suggest that 14,15 EEZE is a partial agonist for the epoxyeicosatrienoic acids/EDHF receptor. These results illustrate an important pharmacological property of this antagonists, which is being increasingly used to study the nature of EDHF.
Authors:
Louise S Harrington; John R Falck; Jane A Mitchell
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  506     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-05-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  165-8     Citation Subset:  IM    
Affiliation:
Unit of Critical Care Medicine, Royal Brompton Hospital, The National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London, SW3 6LY, UK.
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MeSH Terms
Descriptor/Qualifier:
8,11,14-Eicosatrienoic Acid / analogs & derivatives*,  pharmacology*
Animals
Biological Factors / antagonists & inhibitors*
Male
Mesenteric Arteries / drug effects*
Mice
Mice, Inbred C57BL
Vasoconstrictor Agents / antagonists & inhibitors,  pharmacology
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Biological Factors; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 0/endothelium-dependent hyperpolarization factor; 7324-41-6/8,11,14-Eicosatrienoic Acid; 98893-66-4/14,15-episulfide eicosatrienoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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