| Not a simple fat-soluble vitamin: Changes in serum 25-(OH)D levels are predicted by adiposity and adipocytokines in older adults. | |
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MedLine Citation:
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PMID: 20804516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the associations between body adiposity and change in serum 25-(OH)D levels over 2.6 years, and if these associations are mediated by metabolic and inflammatory factors in older adults. METHODS: This is a longitudinal study of 859 randomly selected subjects (mean 62 years, range 51-80, 49% women). Serum 25-hydroxyvitamin D [25-(OH)D] was assessed by radioimmunoassay at baseline and 2.6 years later. Baseline serum level of leptin was assessed by radioimmunoassay and interleukin (IL)-6 by a chemiluminescent immunoassay in the first 183 subjects. RESULTS: In multivariable analyses, body mass index, trunk fat percentage and waist-to-hip ratio were significant predictors of increased incident vitamin D deficiency [a 25-(OH)D < 50 nmol L⁻¹ at follow-up when ≥50 nmol L⁻¹ at baseline] and decreased recovery of vitamin D deficiency [a 25-(OH)D ≥ 50 nmol L⁻¹ at follow-up when < 50 nmol L⁻¹ at baseline]. Change in 25-(OH)D levels per annum was also independently predicted by baseline leptin (β: -0.09/unit, 95% CI: -0.17, -0.03), IL-6 (β: -0.68/quartile, 95% CI: -1.35, -0.02) and total cholesterol/high-density lipoprotein (HDL) ratio (β: -0.51, 95% CI: -0.88, -0.14). The associations between body adiposity measures and change in 25-(OH)D completely disappeared after adjustment for leptin, diminished after adjustment for IL-6, but remained unchanged after adjustment for total cholesterol/HDL ratio. All associations were independent of season and sun exposure. CONCLUSIONS: Body fat is not simply a passive reservoir for 25-(OH)D. In addition to season and sun exposure, 25-(OH)D levels appear to be determined by metabolic and, to a lesser extent, inflammatory factors, and these appear to mediate the effects of adiposity on change in 25-(OH)D. |
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Authors:
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C Ding; V Parameswaran; L Blizzard; J Burgess; G Jones |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of internal medicine Volume: 268 ISSN: 1365-2796 ISO Abbreviation: J. Intern. Med. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: England |
Other Details:
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Languages: eng Pagination: 501-10 Citation Subset: IM |
Copyright Information:
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© 2010 The Association for the Publication of the Journal of Internal Medicine. |
Affiliation:
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Menzies Research Institute, University of Tasmania, Hobart, Tas., Australia. changhai.ding@utas.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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physiology* Aged Aged, 80 and over Aging / physiology* Body Mass Index Cohort Studies Female Humans Interleukin-6 / blood* Leptin / blood* Longitudinal Studies Male Middle Aged Multivariate Analysis Radioimmunoassay Vitamin D / analogs & derivatives*, blood Waist-Hip Ratio |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Leptin; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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