| Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection. | |
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MedLine Citation:
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PMID: 19937696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: Our results demonstrate recognition of HBV patterns by nonparenchymal liver cells, which results in IL-6-mediated control of HBV infection at the transcriptional level. Thus, IL-6 ensures early control of the virus, limiting activation of the adaptive immune response and preventing death of the HBV-infected hepatocyte. This pattern recognition may be essential for a virus, which infects a new host with only a few virions. Our data also indicate that therapeutic neutralization of IL-6 for treatment of certain diseases may represent a risk if the patient is HBV-infected. |
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Authors:
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Marianna Hösel; Maria Quasdorff; Katja Wiegmann; Dennis Webb; Uta Zedler; Mathias Broxtermann; Raindy Tedjokusumo; Knud Esser; Silke Arzberger; Carsten J Kirschning; Anja Langenkamp; Christine Falk; Hildegard Büning; Stefan Rose-John; Ulrike Protzer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 50 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-27 Completed Date: 2009-12-15 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 1773-82 Citation Subset: IM |
Affiliation:
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Center for Molecular Medicine Cologne (ZMMK), University Hospital Cologne, Köln, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Cytokines / biosynthesis Gene Expression Regulation* Hepatitis B / immunology*, metabolism Hepatitis B virus / drug effects, genetics, physiology Hepatocyte Nuclear Factor 1-alpha / antagonists & inhibitors, genetics Hepatocyte Nuclear Factor 4 / antagonists & inhibitors, genetics Hepatocytes / metabolism Humans Interferons / physiology* Interleukin-6 / physiology* MAP Kinase Signaling System NF-kappa B / metabolism Transcription, Genetic Virus Replication |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/HNF4A protein, human; 0/Hepatocyte Nuclear Factor 1-alpha; 0/Hepatocyte Nuclear Factor 4; 0/Interleukin-6; 0/NF-kappa B; 9008-11-1/Interferons |
| Comments/Corrections | |
Comment In:
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Hepatology. 2009 Dec;50(6):1692-5
[PMID:
19937686
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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