Document Detail

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.
MedLine Citation:
PMID:  19937696     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Our results demonstrate recognition of HBV patterns by nonparenchymal liver cells, which results in IL-6-mediated control of HBV infection at the transcriptional level. Thus, IL-6 ensures early control of the virus, limiting activation of the adaptive immune response and preventing death of the HBV-infected hepatocyte. This pattern recognition may be essential for a virus, which infects a new host with only a few virions. Our data also indicate that therapeutic neutralization of IL-6 for treatment of certain diseases may represent a risk if the patient is HBV-infected.
Marianna Hösel; Maria Quasdorff; Katja Wiegmann; Dennis Webb; Uta Zedler; Mathias Broxtermann; Raindy Tedjokusumo; Knud Esser; Silke Arzberger; Carsten J Kirschning; Anja Langenkamp; Christine Falk; Hildegard Büning; Stefan Rose-John; Ulrike Protzer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  50     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-27     Completed Date:  2009-12-15     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1773-82     Citation Subset:  IM    
Center for Molecular Medicine Cologne (ZMMK), University Hospital Cologne, Köln, Germany.
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MeSH Terms
Cells, Cultured
Cytokines / biosynthesis
Gene Expression Regulation*
Hepatitis B / immunology*,  metabolism
Hepatitis B virus / drug effects,  genetics,  physiology
Hepatocyte Nuclear Factor 1-alpha / antagonists & inhibitors,  genetics
Hepatocyte Nuclear Factor 4 / antagonists & inhibitors,  genetics
Hepatocytes / metabolism
Interferons / physiology*
Interleukin-6 / physiology*
MAP Kinase Signaling System
NF-kappa B / metabolism
Transcription, Genetic
Virus Replication
Reg. No./Substance:
0/Cytokines; 0/HNF4A protein, human; 0/Hepatocyte Nuclear Factor 1-alpha; 0/Hepatocyte Nuclear Factor 4; 0/Interleukin-6; 0/NF-kappa B; 9008-11-1/Interferons
Comment In:
Hepatology. 2009 Dec;50(6):1692-5   [PMID:  19937686 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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