Document Detail


Not insulin but insulin sensitivity, leptin, and cortisol are major factors regulating serum acylated ghrelin level in healthy women.
MedLine Citation:
PMID:  17923797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that insulin and glucose are the most important factors for ghrelin secretion. Most of these studies were performed using total ghrelin assays, detecting two forms of ghrelin (acylated and desacyl), derived from the same peptide precursor but having different biological effects. This study was therefore designed to characterize associations between serum acylated ghrelin levels (Ghr), selected adipocytokines, hormones, and carbohydrate metabolism parameters in healthy women in stable energy metabolism. The study was performed on 32 healthy, normal-weight, non-pregnant women with normal [body mass index (BMI) 18.9-24.2 kg/m2] and stable (the difference between two measurements performed within 1 month being less than 0.5 kg) body weight, aged 22-47 yr. Leptin, Ghr, GH, IGF-I, cortisol, insulin, and glucose were measured in the early follicular phase of the menstruation cycle. Insulin sensitivity was measured using quantitative insulin sensitivity check index (QUICKI). Body composition was assessed by bioimpedance. We found a positive linear correlation between leptin and Ghr (r=0.375; p=0.034) and negative correlation between insulin and Ghr (r=-0.374; p=0.034). GH, IGF-I, adiponectin, and body composition parameters did not correlate with Ghr. In multiple regression analysis only QUICKI, leptin, glucose, and cortisol (positively) and age (negatively) accounted for 50% variation of Ghr. Insulin and BMI did not contribute significantly to the model. Our results suggest that in healthy women basal Ghr level is regulated by multiple factors, mainly by insulin sensitivity, leptin, and adrenal glands activity. However, further studies are needed to elucidate the physiological mechanisms involved in acylated Ghr secretion.
Authors:
A Kempa; B Krzyzanowska-Swiniarska; T Miazgowski; K Pilarska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  30     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-09     Completed Date:  2007-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  659-65     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Metabolic Diseases and Internal Diseases, Pomeranian Medical University, Arkoñska 4, 71455 Szczecin, Poland.
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MeSH Terms
Descriptor/Qualifier:
Acylation
Adiponectin / blood
Adrenal Glands / metabolism
Adult
Blood Glucose
Energy Metabolism
Female
Ghrelin
Human Growth Hormone / blood
Humans
Hydrocortisone / blood*
Insulin / blood*
Insulin Resistance*
Insulin-Like Growth Factor I / metabolism
Leptin / blood*
Middle Aged
Peptide Hormones / blood*
Premenopause / metabolism
Regression Analysis
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Blood Glucose; 0/Ghrelin; 0/Leptin; 0/Peptide Hormones; 11061-68-0/Insulin; 12629-01-5/Human Growth Hormone; 50-23-7/Hydrocortisone; 67763-96-6/Insulin-Like Growth Factor I

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