Document Detail

Not all shellfish "allergy" is allergy!
MedLine Citation:
PMID:  22410209     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The popularity of shellfish has been increasing worldwide, with a consequent increase in adverse reactions that can be allergic or toxic. The approximate prevalence of shellfish allergy is estimated at 0.5-2.5% of the general population, depending on degree of consumption by age and geographic regions. The manifestations of shellfish allergy vary widely, but it tends to be more severe than most other food allergens.Tropomyosin is the major allergen and is responsible for cross-reactivity between members of the shellfish family, particularly among the crustacea. Newly described allergens and subtle differences in the structures of tropomyosin between different species of shellfish could account for the discrepancy between in vitro cross-antigenicity and clinical cross-allergenicity. The diagnosis requires a thorough medical history supported by skin testing or measurement of specific IgE level, and confirmed by appropriate oral challenge testing unless the reaction was life-threatening.Management of shellfish allergy is basically strict elimination, which in highly allergic subjects may include avoidance of touching or smelling and the availability of self-administered epinephrine. Specific immunotherapy is not currently available and requires the development of safe and effective protocols.
Chee K Woo; Sami L Bahna
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Publication Detail:
Type:  Journal Article     Date:  2011-06-10
Journal Detail:
Title:  Clinical and translational allergy     Volume:  1     ISSN:  2045-7022     ISO Abbreviation:  Clin Transl Allergy     Publication Date:  2011  
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-10-02     Revised Date:  2012-11-09    
Medline Journal Info:
Nlm Unique ID:  101576043     Medline TA:  Clin Transl Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  3     Citation Subset:  -    
Allergy and Immunology Section, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA.
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