Document Detail

Not all sarcomas developed in irradiated tissue are necessarily radiation-induced - Spectrum of disease and treatment characteristics.
MedLine Citation:
PMID:  22138059     Owner:  NLM     Status:  Publisher    
BACKGROUND: Sarcomas in irradiated tissue (SITs) are often considered with second cancers, although they usually present distinct dose-response, genetic and clinical patterns. The contribution of radiation in SIT development is likely, but remains unproven in many cases. MATERIALS AND METHODS: We reviewed the literature for published data on SITs. RESULTS: SITs incidence ranged between 0.03% and 0.2%. Median latency was 15years. Angiosarcoma was the second most common subtype after undifferentiated sarcomas of malignant fibrous histiocytoma (MFH). C-Myc overexpression can be used to identify radiation-induced angiosarcoma, and a recently described transcriptomic signature of genes involved in chronic oxidative stress and mitochondrial dysfunction may indicate radiation causality. Osteosarcomas were often associated with genetic predisposition. Five-year survival rates rarely exceeded 30% because the therapeutic possibilities were often limited by the first cancer. Chemotherapy response may differ from that of de novo sarcomas. CONCLUSION: SITs present different characteristics from non-sarcomatoid second cancers. Reporting of SIT cases and the establishment of tissue and serum banks is necessary to better understand and validate the recently discovered radiation signature.
Juliette Thariat; Antoine Italiano; Fabrice Collin; Antoine Iannessi; Pierre-Yves Marcy; Alexis Lacout; Isabelle Birtwisle-Peyrottes; Antoine Thyss; Jean-Léon Lagrange
Related Documents :
22706119 -  dna microarray-based gene expression profiling in diagnosis, assessing prognosis and ...
22236239 - Breast-cancer screening.
21598259 - Cervical cancer screening in low- and middle-income countries.
22848209 - Pparg epigenetic deregulation and its role in colorectal tumorigenesis.
21934689 - Is there a genetic cause for cancer cachexia? - a clinical validation study in 1797 pat...
21570109 - Sentinel lymph node mapping for endometrial cancer improves the detection of metastatic...
1577609 - Radioimmunodetection of human colon cancer using 99mtc-mdp-moab-a7 in mice.
22367369 - Different levels of sialyl-tn antigen expressed on muc16 in patients with endometriosis...
20425609 - Neurotoxicity of cancer treatment.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-2
Journal Detail:
Title:  Critical reviews in oncology/hematology     Volume:  -     ISSN:  1879-0461     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8916049     Medline TA:  Crit Rev Oncol Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Department of Radiation Oncology/IBDC CNRS UMR 6543 Institut Universitaire de la Face et du Cou, Antoine-Lacassagne Cancer Center, Nice Sophia-Antipolis University, 33 Av. Valombrose, 06189 Nice Cedex 2, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ultrasonographic Lung Sliding Sign in Confirming Proper Endotracheal Intubation during Emergency Int...
Next Document:  Review: Human trophoblast fusion and differentiation: Lessons from trisomy 21 placenta.