| Not all brands are created equal: a comparison of selected components of different brands of Serenoa repens extract. | |
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MedLine Citation:
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PMID: 15289814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recommendations regarding the use of plant-derived medications for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) state that every brand should be fully evaluated and considered separately. Disparity between a number of brands in terms of their stated and actual doses has been recently highlighted. The aim of this study was to fully quantify the variation in Serenoa repens extracts (SrE) commercially available for the treatment of BPH-associated LUTS. To this end, 14 brands of SrE were compared. Concentrations of free fatty acids (FFAs), methyl and ethyl esters, long-chain esters and glycerides were assessed using liquid and gas chromatography. Many of the brands showed a significantly different proportional content which may have an impact on their clinical efficacy and safety. The high concentrations of FFAs in particular, which previous research has suggested as comprising the active agent of SrE for the treatment of LUTS, may influence the clinical benefit derived from each product. Our findings lend further weight to recommendations by the 5th International Consultation on BPH that plant-derived treatments should be analysed and considered as independent entities despite their common origin. Only extracts with demonstrated pharmacological activities and proven clinical efficacy should be considered for the treatment of patients with BPH. |
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Authors:
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F K Habib; M G Wyllie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Prostate cancer and prostatic diseases Volume: 7 ISSN: 1365-7852 ISO Abbreviation: Prostate Cancer Prostatic Dis. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-09-02 Completed Date: 2005-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815755 Medline TA: Prostate Cancer Prostatic Dis Country: England |
Other Details:
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Languages: eng Pagination: 195-200 Citation Subset: IM |
Affiliation:
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Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, UK. f.k.habib@ed.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Male Phytotherapy* Plant Extracts / chemistry, therapeutic use* Prostatic Hyperplasia / complications*, drug therapy Serenoa* Urinary Tract Infections / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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