Document Detail


Not all reading disabilities are dyslexia: distinct neurobiology of specific comprehension deficits.
MedLine Citation:
PMID:  23273430     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although an extensive literature exists on the neurobiological correlates of dyslexia (DYS), to date, no studies have examined the neurobiological profile of those who exhibit poor reading comprehension despite intact word-level abilities (specific reading comprehension deficits [S-RCD]). Here we investigated the word-level abilities of S-RCD as compared to typically developing readers (TD) and those with DYS by examining the blood oxygenation-level dependent response to words varying on frequency. Understanding whether S-RCD process words in the same manner as TD, or show alternate pathways to achieve normal word-reading abilities, may provide insights into the origin of this disorder. Results showed that as compared to TD, DYS showed abnormal covariance during word processing with right-hemisphere homologs of the left-hemisphere reading network in conjunction with left occipitotemporal underactivation. In contrast, S-RCD showed an intact neurobiological response to word stimuli in occipitotemporal regions (associated with fast and efficient word processing); however, inferior frontal gyrus (IFG) abnormalities were observed. Specifically, TD showed a higher-percent signal change within right IFG for low-versus-high frequency words as compared to both S-RCD and DYS. Using psychophysiological interaction analyses, a coupling-by-reading group interaction was found in right IFG for DYS, as indicated by a widespread greater covariance between right IFG and right occipitotemporal cortex/visual word-form areas, as well as bilateral medial frontal gyrus, as compared to TD. For S-RCD, the context-dependent functional interaction anomaly was most prominently seen in left IFG, which covaried to a greater extent with hippocampal, parahippocampal, and prefrontal areas than for TD for low- as compared to high-frequency words. Given the greater lexical access demands of low frequency as compared to high-frequency words, these results may suggest specific weaknesses in accessing lexical-semantic representations during word recognition. These novel findings provide foundational insights into the nature of S-RCD, and set the stage for future investigations of this common, but understudied, reading disorder.
Authors:
Laurie E Cutting; Amy Clements-Stephens; Kenneth R Pugh; Scott Burns; Aize Cao; James J Pekar; Nicole Davis; Sheryl L Rimrodt
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-04-04
Journal Detail:
Title:  Brain connectivity     Volume:  3     ISSN:  2158-0022     ISO Abbreviation:  Brain Connect     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-24     Completed Date:  2013-11-05     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  101550313     Medline TA:  Brain Connect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-211     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain / blood supply,  pathology*
Child
Comprehension / physiology*
Dyslexia / diagnosis*
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Oxygen / blood
Psychophysics
Vocabulary
Grant Support
ID/Acronym/Agency:
2 UL1 TR000445/TR/NCATS NIH HHS; M01 RR000052/RR/NCRR NIH HHS; M01-RR00052/RR/NCRR NIH HHS; P01 HD001994/HD/NICHD NIH HHS; P30 HD015052/HD/NICHD NIH HHS; P30 HD15052/HD/NICHD NIH HHS; P41 EB015909/EB/NIBIB NIH HHS; P50 HD052121/HD/NICHD NIH HHS; P50HD052121/HD/NICHD NIH HHS; R01 HD044073/HD/NICHD NIH HHS; R01 HD44073/HD/NICHD NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 TR000445/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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