Document Detail

Nosocomial infectious potency of imipenem-resistant Pseudomonas aeruginosa isolated from obstetric and gynecologic infections.
MedLine Citation:
PMID:  12673417     Owner:  NLM     Status:  MEDLINE    
Two hundred and eighty-two strains of Pseudomonas aeruginosa were isolated from patients at the Department of Obstetrics and Gynecology, Gifu University School of Medicine, between 1998 and 2000, and among them, 27 imipenem (IPM)-resistant strains of P. aeruginosa (27/282; 9.6%) were isolated from urine, exudate from surgical wounds, and ascites. Seven of the 27 IPM-resistant P. aeruginosa strains were positive (25.9%) for the bla (imp) gene determined by a polymerase chain reaction (PCR) method, and 4 of them were positive for the aac (6')-Ib gene. No strain of P. aeruginosa had both the bla (imp) and aac(6')-Ib genes. Pulsed-field gel electrophoresis (PFGE) patterns indicated the nosocomial spread of IPM-resistant P. aeruginosa. The presence of IPM-resistant P. aeruginosa carrying the bla (imp) gene might be implicated in possible spreading and outbreaks, and screening for bla (imp)-positive P. aeruginosa, therefore, might be necessary for protection against nosocomial infection.
Xiang-Hua Yin; Hiroshige Mikamo; Teruhiko Tamaya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     Volume:  9     ISSN:  1341-321X     ISO Abbreviation:  J. Infect. Chemother.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-03     Completed Date:  2003-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9608375     Medline TA:  J Infect Chemother     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  97-100     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Division of Organ Pathobiology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Cross Infection / microbiology,  prevention & control*
Disease Outbreaks
Electrophoresis, Gel, Pulsed-Field
Imipenem / pharmacology*
Microbial Sensitivity Tests
Obstetrics and Gynecology Department, Hospital
Polymerase Chain Reaction
Pseudomonas Infections / microbiology,  prevention & control
Pseudomonas aeruginosa / drug effects*,  enzymology
beta-Lactam Resistance*
beta-Lactamases / genetics*
Reg. No./Substance:
0/Anti-Bacterial Agents; 74431-23-5/Imipenem; EC

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