Document Detail

Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: clinical outcome and length of hospitalization.
MedLine Citation:
PMID:  12032895     Owner:  NLM     Status:  MEDLINE    
Population characteristics and outcomes were retrospectively compared for critically ill patients with nosocomial bacteremia caused by antibiotic-susceptible (AB-S; n=208) or antibiotic-resistant (AB-R; n=120) gram-negative bacteria. No significant differences in severity of illness and comorbidity factors were seen between groups. Patients with bacteremia caused by AB-R strains had a longer hospitalization before the onset of the bacteremia. The in-hospital mortality for patients with bacteremia caused by AB-S strains was 41.8%; for patients infected with AB-R strains, it was 45.0% (P=.576). A multivariate survival analysis demonstrated that older age (P=.009), a high-risk source of bacteremia (abdominal and lower respiratory tract; P=.031), and a high acute physiology and chronic health evaluation II-related expected mortality (P=.032) were independently associated with in-hospital mortality (P<.05). Antibiotic resistance in nosocomial bacteremia caused by gram-negative bacteria does not adversely affect the outcome for critically ill patients.
Stijn Blot; Koenraad Vandewoude; Dirk De Bacquer; Francis Colardyn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-05-23
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  34     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-28     Completed Date:  2002-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1600-6     Citation Subset:  IM    
Department of Intensive Care, Ghent University Hospital, B-9000 Ghent, Belgium.
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MeSH Terms
Bacteremia / microbiology*,  mortality
Cohort Studies
Critical Illness
Cross Infection / microbiology*,  mortality
Drug Resistance*
Gram-Negative Bacteria
Gram-Negative Bacterial Infections / mortality*
Intensive Care Units
Length of Stay
Middle Aged
Outcome Assessment (Health Care)
Retrospective Studies
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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