Document Detail

Nosocomial Clostridium difficile reservoir in a neonatal intensive care unit.
MedLine Citation:
PMID:  6494014     Owner:  NLM     Status:  MEDLINE    
A new bacteriophage/bacteriocin typing system was used to study Clostridium difficile colonization in a neonatal intensive care unit. C. difficile was isolated from 21 of 62 (34%) stools from 15 of 37 (41%) infants. Colonization was reduced during antimicrobial therapy and for about 1 week thereafter. One of five nurses and one of two parents studied were carriers. Eight isolates were cultured from environmental surfaces. Thirty of 31 C. difficile isolates were found to be a single type, Cld 6,9,10,13; bacteriocin 1320,1537,2304. No C. difficile was found in 29 specimens obtained in the delivery room from mothers and infants, and there was no association of early colonization with vaginal delivery. The data provide strong evidence for nosocomial acquisition of C. difficile by infants in the neonatal intensive care unit. No obvious pathologic role for C. difficile could be identified among colonized infants. Among 22 C. difficile isolates from 7 adult inpatients with diarrhea and 13 healthy infants attending the center's well baby clinic, 4 were the same type as the strain found in the intensive care nursery. Only one of these patients had had direct contact with the neonatal intensive care unit, indicating that the nursery strain may also be found elsewhere in the community.
A J Zedd; T L Sell; D R Schaberg; F R Fekety; M S Cooperstock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric infectious disease     Volume:  3     ISSN:  0277-9730     ISO Abbreviation:  Pediatr Infect Dis     Publication Date:    1984 Sep-Oct
Date Detail:
Created Date:  1984-12-10     Completed Date:  1984-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8209468     Medline TA:  Pediatr Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  IM    
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MeSH Terms
Carrier State / microbiology*
Clostridium / isolation & purification
Clostridium Infections / diagnosis,  etiology*
Cross Infection / diagnosis,  etiology*
Disease Reservoirs*
Equipment Contamination
Feces / microbiology
Infant, Newborn
Intensive Care Units, Neonatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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