| The North American Immune Tolerance Registry: practices, outcomes, outcome predictors. | |
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MedLine Citation:
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PMID: 11848456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The North American Immune Tolerance Registry was initiated to study of immune tolerance (ITT) in Canada and the United States with respect to: 1) therapeutic regimens in use for haemophilia A (HA) and B (HB) inhibitor patients; 2) therapeutic outcomes; 3) potential predictors of successful outcome and 4) complications of therapy. Data on 188 ITT courses was collected by questionnaire from 60 haemophilia centers from 1993-99. Among the completed courses, the overall success rate was 70% (115/164) for all HA and 31% (5/16) for all HB. Outcome parameters noted to be predictive of ITT success for all HA were 1) pre-ITT induction (p = 0.003), 2) ITT peak (p = 0.007) and 3) historical pre ITT peak (p = 0.04) inhibitor titres. An inverse correlation between total daily dose (units/kg/day) and success: (80% with under 50; 71% with 50-99; 73% with 100-199; and 41% with > or = 200, p = 0.01) was found. Outcome predictors were not evaluable for HB, although adverse reactions to therapy, including nephrotic syndrome, and access complications were more common among failed courses. Infection most often complicated the use of access catheters. These results are discussed within the context of the international ITT registry and upcoming prospective ITT study. |
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Authors:
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D M DiMichele; B L Kroner; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 87 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-02-18 Completed Date: 2002-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 52-7 Citation Subset: IM |
Affiliation:
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New York Presbyterian Hospital, Weill Medical of College of Cornell, New York 10021, USA. dmdimich@med.cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Canada
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epidemiology Catheterization, Central Venous / adverse effects Cohort Studies Comorbidity Desensitization, Immunologic* / statistics & numerical data, utilization Factor IX / immunology*, therapeutic use Factor VIII / immunology*, therapeutic use Female HIV Infections / epidemiology, immunology Hemophilia A / epidemiology, immunology*, therapy Hemophilia B / epidemiology, immunology*, therapy Hemorrhage / etiology Humans Immune Tolerance* Immunization Isoantibodies / blood, immunology* Male Outcome Assessment (Health Care) Questionnaires Recombinant Proteins / immunology, therapeutic use Registries / statistics & numerical data* Retrospective Studies Treatment Outcome United States / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Isoantibodies; 0/Recombinant Proteins; 9001-27-8/Factor VIII; 9001-28-9/Factor IX |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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