Document Detail


Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway.
MedLine Citation:
PMID:  18346044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that norsolorinic acid induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of norsolorinic acid-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of norsolorinic acid in MCF-7 cells.
Authors:
Clay C C Wang; Yi-Ming Chiang; Po-Lin Kuo; Jiunn-Kae Chang; Ya-Ling Hsu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-16
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  102     ISSN:  1742-7843     ISO Abbreviation:  Basic Clin. Pharmacol. Toxicol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-16     Completed Date:  2008-06-12     Revised Date:  2013-09-02    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  491-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Pharmaceutical Science, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy*,  metabolism,  pathology
Anthraquinones / isolation & purification,  pharmacology*
Antigens, CD95 / metabolism*
Antineoplastic Agents, Phytogenic / isolation & purification,  pharmacology*
Apoptosis / drug effects
Aspergillus / chemistry*
Breast Neoplasms / drug therapy*,  metabolism,  pathology
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Fas Ligand Protein / metabolism*
Female
Humans
Plant Extracts
Tumor Markers, Biological / metabolism
Grant Support
ID/Acronym/Agency:
GM075857/GM/NIGMS NIH HHS; R01 GM075857/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anthraquinones; 0/Antigens, CD95; 0/Antineoplastic Agents, Phytogenic; 0/Fas Ligand Protein; 0/Plant Extracts; 0/Tumor Markers, Biological; 78371-59-2/norsolorinic acid
Comments/Corrections

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