Document Detail


Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
MedLine Citation:
PMID:  19848433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five new steroids, norselic acids A-E (1-5), were isolated from the sponge Crella sp. collected in Antarctica. The planar structures of the norselic acids were established by extensive NMR spectroscopy and mass spectrometry studies, and the configuration of norselic acid A (1) was elucidated by X-ray crystallography. Norselic acid A displays antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-sensitive S. aureus (MSSA), vancomycin-resistant Enterococcus faecium (VRE), and Candida albicans and reduces consumption of food pellets by sympatric mesograzers. Compounds 1-5 are also active against the Leishmania parasite at low micromolar levels.
Authors:
Wai S Ma; Tina Mutka; Brian Vesley; Margaret O Amsler; James B McClintock; Charles D Amsler; Jason A Perman; Maya P Singh; William M Maiese; Michael J Zaworotko; Dennis E Kyle; Bill J Baker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of natural products     Volume:  72     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-23     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1842-6     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antarctic Regions
Anti-Infective Agents / chemistry,  isolation & purification*,  pharmacology*
Candida albicans / drug effects
Enterococcus faecium / drug effects
Leishmania / drug effects
Methicillin Resistance / drug effects
Methicillin-Resistant Staphylococcus aureus / drug effects*
Microbial Sensitivity Tests
Molecular Structure
Porifera / chemistry*
Staphylococcal Infections / drug therapy
Steroids / chemistry,  isolation & purification*,  pharmacology*
Vancomycin Resistance / drug effects
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Steroids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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