| Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. | |
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MedLine Citation:
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PMID: 19848433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five new steroids, norselic acids A-E (1-5), were isolated from the sponge Crella sp. collected in Antarctica. The planar structures of the norselic acids were established by extensive NMR spectroscopy and mass spectrometry studies, and the configuration of norselic acid A (1) was elucidated by X-ray crystallography. Norselic acid A displays antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-sensitive S. aureus (MSSA), vancomycin-resistant Enterococcus faecium (VRE), and Candida albicans and reduces consumption of food pellets by sympatric mesograzers. Compounds 1-5 are also active against the Leishmania parasite at low micromolar levels. |
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Authors:
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Wai S Ma; Tina Mutka; Brian Vesley; Margaret O Amsler; James B McClintock; Charles D Amsler; Jason A Perman; Maya P Singh; William M Maiese; Michael J Zaworotko; Dennis E Kyle; Bill J Baker |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of natural products Volume: 72 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-23 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1842-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antarctic Regions Anti-Infective Agents / chemistry, isolation & purification*, pharmacology* Candida albicans / drug effects Enterococcus faecium / drug effects Leishmania / drug effects Methicillin Resistance / drug effects Methicillin-Resistant Staphylococcus aureus / drug effects* Microbial Sensitivity Tests Molecular Structure Porifera / chemistry* Staphylococcal Infections / drug therapy Steroids / chemistry, isolation & purification*, pharmacology* Vancomycin Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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