Document Detail


Normoxic and Hyperoxic Cardiopulmonary Bypass in Congenital Heart Disease.
MedLine Citation:
PMID:  25328889     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cyanotic congenital heart disease comprises a diverse spectrum of anatomical pathologies. Common to all, however, is chronic hypoxia before these lesions are operated upon when cardiopulmonary bypass is initiated. A range of functional and structural adaptations take place in the chronically hypoxic heart, which, whilst protective in the hypoxic state, are deleterious when the availability of oxygen to the myocardium is suddenly improved. Conventional cardiopulmonary bypass delivers hyperoxic perfusion to the myocardium and is associated with cardiac injury and systemic stress, whilst a normoxic perfusate protects against these insults.
Authors:
Amir Mokhtari; Martin Lewis
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Publication Detail:
Type:  REVIEW     Date:  2014-9-18
Journal Detail:
Title:  BioMed research international     Volume:  2014     ISSN:  2314-6141     ISO Abbreviation:  Biomed Res Int     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-20     Completed Date:  -     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  101600173     Medline TA:  Biomed Res Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  678268     Citation Subset:  -    
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