Document Detail

Normothermic versus hypothermic perfusion during primary coronary artery bypass grafting.
MedLine Citation:
PMID:  8574537     Owner:  NLM     Status:  MEDLINE    
Normothermic versus hypothermic cardiopulmonary bypass was evaluated in 1442 consecutive patients undergoing primary coronary artery bypass grafting (CABG). Group 1 (n = 545) were operated on in moderate systemic hypothermia (rectal temperature 28 degrees C) and group 2 (n = 897) in normothermia (rectal temperature 37 degrees C). Both groups had cold cardioplegic arrest (10 degrees C) and local cooling of the heart with slush. Anaesthesia and operative techniques were identical in both groups. The mean age was 60 years; group 2 contained significantly more patients aged > 65 years (P < 0.05) and had more frequent emergency operations (P < 0.001) than group 1. Other preoperative patient characteristics were similar between groups. Aortic cross-clamping time was similar in both groups but cardiopulmonary bypass time was significantly longer in group 1 than in group 2 (97.9(28.8) versus 76.6(26.0) min, P < 0.001). Perioperative mortality rate was 3.3% in group 1 and 2.6% in group 2. The incidence of myocardial infarction was significantly higher in group 1 than in group 2 (2.0% versus 0.7%) Perioperative low cardiac output needing inotropic support was similar in both groups, but group 1 patients required more intra-aortic balloon insertions (4.6% versus 2.2%, P < 0.05). Lower incidence of postoperative ventricular arrhythmias, shorter intubation time and less transient renal failures were significant in group 2 compared with those in group 1 (P < 0.001), while re-exploration of bleeding, wound infections, pulmonary, neurological and gastrointestinal complications did not differ. Blood transfusion was less in group 2 (1.2(1.1) units, P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
J T Christenson; J Maurice; F Simonet; V Velebit; M Schmuziger
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  3     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-13     Completed Date:  1996-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  519-24     Citation Subset:  IM    
Cardiovascular Unit, Hôpital de la Tour, Meyrin, Geneva.
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MeSH Terms
Aged, 80 and over
Cardiopulmonary Bypass*
Coronary Artery Bypass*
Heart Arrest, Induced
Hypothermia, Induced*
Intraoperative Complications
Middle Aged
Postoperative Complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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