Document Detail

Normotensive blood pressure in mice with a disrupted renin Ren-1d gene.
MedLine Citation:
PMID:  9167266     Owner:  NLM     Status:  MEDLINE    
Renin is an aspartyl protease that is involved in the conversion of angiotensinogen to angitensin II and hence participates in the regulation of blood pressure. Mice are polymorphic for the number of renin genes with some strains harbouring two renin genes, Ren-1d and Ren-2. To study the role of renin Ren-1d in regulating cardiovascular homeostasis, mice with a disrupted Ren-1d gene were created. Analyses of kidney renin mRNA expression in Ren-1d-/-/Ren-2+/+ mice demonstrated that only Ren-2 transcripts were present. Mean arterial blood pressures of Ren-1d+/+/Ren-2+/+, Ren-1d+/-/Ren-2+/+ and Ren-1d-/-/Ren-2+/+ mice showed no significant differences. These observations demonstrate that the Ren-1d gene product is not essential for normal blood pressure maintenance under normal physiological conditions.
F Bertaux; W H Colledge; S E Smith; M Evans; N J Samani; C C Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transgenic research     Volume:  6     ISSN:  0962-8819     ISO Abbreviation:  Transgenic Res.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-23     Completed Date:  1997-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9209120     Medline TA:  Transgenic Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  191-6     Citation Subset:  IM    
Department of Neuroscience, Institute of Psychiatry, London, UK.
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MeSH Terms
Blood Pressure / genetics*,  physiology
Blotting, Southern
Kidney / metabolism
Mice, Knockout
Mice, Transgenic / physiology*
Polymerase Chain Reaction
RNA, Messenger / analysis,  metabolism
Recombination, Genetic
Renin / genetics*
Stem Cells / physiology
Transcription, Genetic
Reg. No./Substance:
0/RNA, Messenger; EC

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