| Normocapnic high frequency oscillatory hyperventilation increases oxygenation in pigs. | |
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MedLine Citation:
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PMID: 21812523 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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High frequency oscillatory ventilation (HFOV), contrary to conventional ventilation, enables a safe increase in tidal volume (V(T)) without endangering alveoli by volutrauma or barotrauma. The aim of the study is to introduce the concept of normocapnic high frequency oscillatory hyperventilation and to assess its effect upon oxygen gain under experimental conditions. Laboratory pigs (n=9) were investigated under total intravenous anesthesia in three phases. Phase 1: Initial volume controlled HFOV period. Phase 2: Hyperventilation - V(T) was increased by (46+/-12) % when compared to normocapnic V(T) during phase 1. All other ventilatory parameters were unchanged. A significant increase in PaO(2) (by 3.75+/-0.52 kPa, p<0.001) and decrease in PaCO(2) (by -2.05+/-0.31 kPa, p<0.001) were obtained. Phase 3: Normocapnia during hyperventilation was achieved by an iterative increase in the CO(2) fraction in the inspiratory gas by a CO(2) admixture. All ventilatory parameters were unchanged. A significant increase in PaO(2) (by 3.79+/-0.73 kPa, p<0.001), similar to that which was observed in phase 2, was preserved in phase 3 whereas normocapnia was fully re-established. The concept of high frequency normocapnic hyperventilation offers a lung protective strategy that significantly improves oxygenation whilst preserving normocapnia. |
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Authors:
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K Roubík; J Pachl; V Zábrodský |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-1 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: - ISSN: 1802-9973 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Czech Technical University in Prague, Faculty of Biomedical Engineering, Kladno, Czech Republic. roubik@fbmi.cvut.cz. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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