| Normalized upper cervical spinal cord atrophy in multiple sclerosis. | |
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MedLine Citation:
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PMID: 18318794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: To find an optimal normalizing factor for upper cervical spinal cord area (UCCA) and to establish whether, in a cross-sectional study, the normalized UCCA correlates better with the neurological disability than the absolute measurement in multiple sclerosis patients. METHODS: UCCA and three potential normalizing factors were estimated from magnetic resonance imaging data in 51 control subjects. Their reliability was assessed and the linear relationships between UCCA and three potential correction factors were investigated. UCCA was then normalized by these factors respectively. On the basis of these results, an optimal factor was selected and applied to 29 MS subjects. RESULTS: An extremely strong correlation between UCCA and LECA was seen (r= .88, P < .01). The coefficient of variation (COV) of UCCA was reduced to 4.4% from 9.3% after correction by LECA. The normalized measurement of UCCA correlated better with the expanded disability status scale (EDSS) than the absolute measurement especially in relapsing-remitting multiple sclerosis patients. Moreover, more spinal cord atrophy was identified in corrected data than uncorrected data. CONCLUSION: Our findings suggest that LECA is an optimal correction factor for UCCA and normalized UCCA is preferable to absolute measurement in cross-sectional study. |
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Authors:
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Feng Song; Yi Huan; Hong Yin; Yali Ge; Guangquan Wei; Yingjuan Chang; Haitao Zhao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 18 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-09-23 Completed Date: 2009-02-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: 320-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Atrophy / pathology Cervical Vertebrae / pathology* Cross-Sectional Studies Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging* Male Middle Aged Multiple Sclerosis / pathology* Reproducibility of Results Spinal Cord / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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