Document Detail

Normalized left ventricular volumes and function in thalassemia major patients with normal myocardial iron.
MedLine Citation:
PMID:  17520718     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the reference range in thalassemia major (TM) for left ventricular (LV) function. MATERIALS AND METHODS: We used cardiovascular magnetic resonance (CMR) to measure heart volumes and function in 81 TM patients with normal myocardial T2* measurements (T2* > 20 msec) and by inference without excess myocardial iron. Forty age- and gender-matched healthy controls were also studied. RESULTS: Resting LV volumes and function normalized to body surface area differed significantly between TM patients and controls. The lower limit and the mean for ejection fraction (EF) were higher in TM patients (males 59 vs. 55%, mean 71% vs. 65%; females 63 vs. 59%, mean 71% vs. 67%; both P < 0.001). The upper limit and mean for end-diastolic volume index were higher in TM patients (males 152 vs. 105 mL/m(2), mean 97 vs. 84 mL/m(2); females 121 vs. 99 mL/m(2), mean 87 vs. 79 mL/m(2); both P < 0.05). In TM patients the cardiac index (P < 0.001) was increased. CONCLUSION: At rest, TM patients with a normal myocardial T2* have different "normal" values for LV volume and function parameters compared to controls, and this has the potential to lead to a misdiagnosis of cardiomyopathy. We present new reference "normal" ranges in TM to alleviate this problem.
Mark A Westwood; Lisa J Anderson; Alicia M Maceira; Farrukh T Shah; Emma Prescott; John B Porter; Beatrix Wonke; J Malcolm Walker; Dudley J Pennell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  25     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-08-10     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1147-51     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Cardiovascular MR Unit, Royal Brompton Hospital and Imperial College, London, United Kingdom.
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MeSH Terms
Case-Control Studies
Chi-Square Distribution
Iron / metabolism
Magnetic Resonance Imaging / methods*
Myocardium / metabolism
Organ Size
Reference Values
Statistics, Nonparametric
Ventricular Function / physiology*
beta-Thalassemia / physiopathology*
Grant Support
//Wellcome Trust
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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