| Normalization of hematocrit with recombinant human erythropoietin in chronic hemodialysis patients does not fully improve their exercise tolerance abilities. | |
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MedLine Citation:
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PMID: 8967885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the recombinant human erythropoietin (rHuEPO) treatment of renal anemia, the target level has widely been accepted as approximately 30% of hematocrit (Hct) which means only partial improvement of the anemia. We tried to maintain 1 female and 9 male patients within a normal Hct and to estimate their exercise tolerance abilities. During the study, no serious complications were experienced. Their maximal oxygen uptake (VO2max), evaluated for 1-6 months after reaching the desired Hct of 35-40% with rHuEPO, was 30.7 +/- 2.4 ml of O2/kg/min. These results were significantly higher than those of the control groups whose Hct levels were maintained at around 30%. Although 1 female and 2 male patients were considered to be within the normal exercise tolerance abilities, the others showed lower values in comparison with the Japanese age- and sex-matched values. Thus, it is not always possible to regain full exercise tolerance abilities even after restoring a normal Hct. Unknown factors besides anemia impairing their exercise tolerance abilities might exist in chronic dialysis patients. |
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Authors:
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M Suzuki; M Tsutsui; A Yokoyama; Y Hirasawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Artificial organs Volume: 19 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-12-03 Completed Date: 1996-12-03 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1258-61 Citation Subset: IM |
Affiliation:
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Kidney Center and Cardiology Section, Shinraku-En Hospital, Niigata, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia / drug therapy* Animals Combined Modality Therapy Cricetinae Erythropoietin / administration & dosage, pharmacology, therapeutic use* Exercise Test Female Guinea Pigs Hematocrit* Humans Male Middle Aged Oxygen Consumption / drug effects Recombinant Proteins / administration & dosage, pharmacology, therapeutic use* Renal Dialysis / standards* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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