Document Detail

Normalization by cell fusion of sister chromatid exchange in Bloom syndrome lymphocytes.
MedLine Citation:
PMID:  7221565     Owner:  NLM     Status:  MEDLINE    
Fusion of fresh lymphocytes from a Bloom syndrome (BS) patient with those of normal subjects or a BS heterozygote resulted in complete normalization of the frequency of sister chromatid exchanges in the chromosomes of BS cells. This normalization took place by the first mitosis in hybrid cells. In contrast, cultivation of BS lymphocytes with those of normal subjects or the BS heterozygote had no effect on sister chromatid exchanges. The cell fusion experiments suggest that the normalization on the sister chromatid exchanges. The cell fusion experiments suggest that the normalization of the sister chromatid exchange frequencies in BS cells can be achieved by factors conserved in the cells of various mammalian species. These findings are compatible with the concept that BS is a recessive genetic mutation at regulatory levels of the DNA repair function.
Y Shiraishi; S Matsui; A A Sandberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  212     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-06-25     Completed Date:  1981-06-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  820-2     Citation Subset:  IM    
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MeSH Terms
Cell Fusion
Cells, Cultured
Crossing Over, Genetic*
Hybrid Cells / physiology
Photosensitivity Disorders / genetics*
Sister Chromatid Exchange*
Telangiectasis / genetics*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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