Document Detail

Normalization of blood pressure and plasma concentrations of beta-endorphin and leucine-enkephalin in patients with primary hypertension after treatment with clonidine.
MedLine Citation:
PMID:  2455169     Owner:  NLM     Status:  MEDLINE    
Opioid peptides are thought to be involved in blood pressure regulation, possibly via an interaction with the sympathetic nervous system (CNS). To further elucidate this hypothesis the plasma concentrations of beta-endorphin, leucine-enkephalin and noradrenaline were determined overnight (9 p.m. to 8 a.m.) in young patients with mild essential hypertension and then compared to normotensive controls. The mean concentrations of beta-endorphin during the early night (9 p.m. to 2 a.m.) and leucine-enkephalin were lower (p less than 0.05, p less than 0.01, respectively) than in the normotensive subjects, but the noradrenaline concentration was higher. After 14 days of treatment with clonidine, which decreases sympathetic activity via a central action, beta-endorphin, leucine-enkephalin, and noradrenaline concentrations did not differ between both groups. It is concluded that the lower plasma concentrations of beta-endorphin and leucine-enkephalin in the hypertensive group could reflect reduced opioidergic activity in the CNS and in the peripheral sympathetic neurons and also could be involved in the increased sympathetic activity of these patients. Besides via sympathetic inhibition, clonidine also may reduce the increased blood pressure further by normalizing central beta-endorphin release.
K Kraft; R Theobald; R Kolloch; K O Stumpe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 12     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-07-29     Completed Date:  1988-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S147-51     Citation Subset:  IM    
Medical Polyclinic, University of Bonn, F.R.G.
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MeSH Terms
Blood Pressure
Clonidine / therapeutic use*
Enkephalin, Leucine / blood*
Hydrocortisone / blood
Hypertension / blood,  drug therapy*,  physiopathology
Norepinephrine / blood
Renin / blood
beta-Endorphin / blood*
Reg. No./Substance:
4205-90-7/Clonidine; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 58822-25-6/Enkephalin, Leucine; 60617-12-1/beta-Endorphin; EC

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