| Normalization of abnormal T-waves during stress testing does not identify patients with reversible perfusion defects. | |
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MedLine Citation:
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PMID: 17680621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine if T-wave normalization during exercise or dobutamine stress testing identified patients with myocardial ischemia as indicated by reversible perfusion defects. METHODS: Exercise or dobutamine stress tests with perfusion scintigraphy were performed in 1,173 patients with abnormal T-waves on their baseline electrocardiograms. The results of perfusion scintigraphy were compared in patients with and without stress-induced T-wave normalization. RESULTS: Only 33 of 270 patients with reversible perfusion defects (12.2%) had T-wave normalization during stress while 76.4% of 140 patients who had T-wave normalization during stress did not have a reversible perfusion defect. Results were similar for patients who did or did not reach 85% of their maximal predicted heart rate, for patients with and without Q-wave infarction on the baseline EKG and for patients who did or did not have ischemic ST-segment depression during stress. CONCLUSIONS: T-wave normalization during stress testing has low sensitivity and poor positive predictive value for stress-induced reversible myocardial ischemia. |
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Authors:
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Henry S Loeb; Nicholas C Friedman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 30 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-13 Completed Date: 2008-03-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 403-7 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley Periodicals, Inc. |
Affiliation:
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Department of Cardiology, Edward Hines Jr. Veterans Affairs Hospital, Hines, Illinois 60141, USA. HSL4134@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atropine / diagnostic use Blood Pressure / drug effects Cardiotonic Agents / diagnostic use Case-Control Studies Dobutamine / diagnostic use Electrocardiography* Exercise Test* Female Heart Conduction System / drug effects, physiopathology* Heart Rate / drug effects Humans Male Middle Aged Myocardial Ischemia / diagnosis*, etiology, physiopathology* Myocardial Reperfusion* Organophosphorus Compounds / diagnostic use Organotechnetium Compounds / diagnostic use Radiopharmaceuticals / diagnostic use Regression Analysis Research Design Retrospective Studies Sensitivity and Specificity Stress, Physiological / complications Technetium Tc 99m Sestamibi / diagnostic use Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; 109581-73-9/Technetium Tc 99m Sestamibi; 34368-04-2/Dobutamine; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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