Document Detail


Normalisation of red blood cell pyruvate kinase in pyruvate kinase deficiency by riboflavin treatment.
MedLine Citation:
PMID:  1139778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A patient with an erythrocyte glutathione reductase activity of 50% of the normal value and an abnormal pyruvate kinase (PK) was given 36 mg riboflavin daily for 6 months. The glutathione reductase activity was restored and the abnormal pyruvate kinase was converted to normal. The clinical state of the patient improved. It can be concluded that the abnormality of PK, at least with this patient, is a secondary effect. Therefore, it is suggested that other abnormalities be searched for when an altered PK is detected. Treatment of this abnormality will help the patients more efficiently.
Authors:
G E Staal; T J van Berkel; J G Nijessen; J F Koster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  60     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-10-10     Completed Date:  1975-10-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  323-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Carbohydrate Metabolism, Inborn Errors / drug therapy*,  enzymology
Drug Stability
Erythrocytes / drug effects,  enzymology*
Glutathione Reductase / metabolism
Hot Temperature
Humans
Kinetics
Pyruvate Kinase / metabolism*
Riboflavin / pharmacology,  therapeutic use*
Time Factors
Chemical
Reg. No./Substance:
83-88-5/Riboflavin; EC 1.8.1.7/Glutathione Reductase; EC 2.7.1.40/Pyruvate Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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